Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Zfp36l3em1/Cya
Common Name:
Zfp36l3-KO
Product ID:
S-KO-09587
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Zfp36l3-KO
Strain ID
KOCMP-333473-Zfp36l3-B6J-VA
Gene Name
Zfp36l3
Product ID
S-KO-09587
Gene Alias
-
Background
C57BL/6JCya
NCBI ID
333473
Modification
Conventional knockout
Chromosome
X
Phenotype
MGI:3525151
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Zfp36l3em1/Cya mice (Catalog S-KO-09587) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000071711
NCBI RefSeq
NM_001009549
Target Region
Exon 1
Size of Effective Region
~2.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Zfp36l3 is a member of the zinc finger protein 36 (ZFP36) family, which is involved in post-transcriptional regulation of messenger RNA (mRNA) metabolism [1]. It contains two tandemly repeated CCCH-type zinc-finger motifs and binds to adenine uridine-rich elements in the 3'-untranslated regions of specific mRNA, leading to target mRNA decay [1]. This gene is unique to rodents and is located on the X chromosome [2,3]. Zfp36l3 is particularly important for placental and extra-embryonic tissue function, suggesting its significance in female reproductive physiology and overall fecundity [2-4]. Genetic models, especially mouse models, are valuable for studying Zfp36l3's functions.

In Zfp36l3 knockout (KO) mice, neonatal survival rates decreased, indicating its importance for offspring survival [4]. RNA-Seq analysis of placental mRNA from KO mice showed many up-regulated transcripts, suggesting these are potential ZFP36L3 target mRNAs [4]. Among them, the type 1 transferrin receptor mRNA was unexpectedly decreased in KO placentas, despite increased stability in KO stem cells [4]. Since this receptor is crucial for placental iron uptake, and its decrease was accompanied by decreased iron stores in the KO fetus, Zfp36l3 may be linked to placental iron metabolism [4].

In conclusion, Zfp36l3 is a rodent-specific gene playing essential roles in placental function, female fecundity, and potentially placental iron metabolism as revealed by KO mouse models. Understanding Zfp36l3 contributes to insights into rodent reproductive biology and potential implications for intrauterine deficiencies that may have long-term consequences.

References:

1. Makita, Sohei, Takatori, Hiroaki, Nakajima, Hiroshi. 2021. Post-Transcriptional Regulation of Immune Responses and Inflammatory Diseases by RNA-Binding ZFP36 Family Proteins. In Frontiers in immunology, 12, 711633. doi:10.3389/fimmu.2021.711633. https://pubmed.ncbi.nlm.nih.gov/34276705/

2. Gingerich, Timothy J, Stumpo, Deborah J, Lai, Wi S, Steppan, Scott J, Blackshear, Perry J. 2015. Emergence and evolution of Zfp36l3. In Molecular phylogenetics and evolution, 94, 518-530. doi:10.1016/j.ympev.2015.10.016. https://pubmed.ncbi.nlm.nih.gov/26493225/

3. Blackshear, Perry J, Phillips, Ruth S, Ghosh, Sanjukta, Richfield, Eric K, Lai, Wi S. 2005. Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. In Biology of reproduction, 73, 297-307. doi:. https://pubmed.ncbi.nlm.nih.gov/15814898/

4. Stumpo, Deborah J, Trempus, Carol S, Tucker, Charles J, Bortner, Donna M, Blackshear, Perry J. 2016. Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. In Development (Cambridge, England), 143, 1424-33. doi:10.1242/dev.130369. https://pubmed.ncbi.nlm.nih.gov/26952984/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest