Ttc16, or Tetratricopeptide repeat protein 16, is a gene that has been implicated in multiple biological processes and disease-related pathways. The tetratricopeptide repeat motif is known to mediate protein-protein interactions, suggesting that Ttc16 may play a role in various cellular functions through interacting with other proteins, although the exact function and associated pathways are still being explored [2,3,4].

In a case-control study comparing extracellular vesicle proteins in diabetic and non-diabetic ischemic stroke patients, Ttc16 was among the proteins that exhibited significant differences in the diabetic stroke (DS) group, indicating its potential role in stroke management and prevention [1]. In a multiomic sequencing study of intermediate-to high-risk cutaneous squamous cell carcinoma, Ttc16 was identified as a key driver mutation, with pathway enrichment in replicative senescence, cellular response to UV, cell-cell adhesion, and cell cycle [3]. Also, in the development of a prognostic risk model for colorectal cancer, Ttc16 was found to function as an independent prognostic factor, with a high risk score associated with poor overall survival, and it was related to cancer stem cell and immune cell infiltration [4].

In conclusion, Ttc16 appears to be involved in multiple disease-related processes such as stroke, cutaneous squamous cell carcinoma, and colorectal cancer. These findings from various studies contribute to our understanding of the role of Ttc16 in disease development, highlighting its potential as a biomarker or therapeutic target in these disease areas.

References:

1. Qadri, Shahnaz, Sohail, Muhamad U, Akhtar, Naveed, Parray, Aijaz, Schmidt, Frank. 2024. Mass spectrometry-based proteomic profiling of extracellular vesicle proteins in diabetic and non-diabetic ischemic stroke patients: a case-control study. In Frontiers in molecular biosciences, 11, 1387859. doi:10.3389/fmolb.2024.1387859. https://pubmed.ncbi.nlm.nih.gov/38948080/

2. Nair, Janaki M, Chauhan, Ganesh, Prasad, Gauri, Tandon, Nikhil, Bharadwaj, Dwaipayan. 2025. Novel genetic associations with childhood adipocytokines in Indian adolescents. In Cytokine, 190, 156935. doi:10.1016/j.cyto.2025.156935. https://pubmed.ncbi.nlm.nih.gov/40187068/

3. Nassir, Shams, Yousif, Miranda, Li, Xing, Pittelkow, Mark R, Mangold, Aaron R. 2025. Multiomic Sequencing of Intermediate- to High-Risk Cutaneous Squamous Cell Carcinoma Identifies Critical Genes and Expression Patterns Associated with Disease and Poor Outcomes. In The Journal of investigative dermatology, , . doi:10.1016/j.jid.2025.01.015. https://pubmed.ncbi.nlm.nih.gov/39884456/

4. Zhang, Jian, Ambe, Peter C, Shaukat, Aasma. 2025. Development of a prognostic risk model for colorectal cancer and association of the prognostic model with cancer stem cell and immune cell infiltration. In Journal of gastrointestinal oncology, 16, 77-91. doi:10.21037/jgo-2024-985. https://pubmed.ncbi.nlm.nih.gov/40115909/