C57BL/6JCya-Batf3em1/Cya
Common Name
Batf3-KO
Product ID
S-KO-09744
Backgroud
C57BL/6JCya
Strain ID
KOCMP-381319-Batf3-B6J-VA
When using this mouse strain in a publication, please cite “Batf3-KO Mouse (Catalog S-KO-09744) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Batf3-KO
Strain ID
KOCMP-381319-Batf3-B6J-VA
Gene Name
Product ID
S-KO-09744
Gene Alias
Snft, 9130211I03Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000027943
NCBI RefSeq
NM_030060
Target Region
Exon 3
Size of Effective Region
~0.5 kb
Overview of Gene Research
Batf3, a transcription factor, is crucial for the development of mucosal conventional DCs type 1 (cDC1) [2]. It is also involved in various immune-related pathways, playing an important role in the cross-presentation of antigens, T cell-mediated immunity, and maintaining intestinal epithelial homeostasis. Genetic models, such as gene knockout (KO) mouse models, have been instrumental in studying Batf3's functions.
In Batf3 -/- mice, CD8α+ dendritic cell development was ablated, leading to defective cross-presentation and lack of virus-specific CD8+ T cell responses to West Nile virus. Also, rejection of highly immunogenic syngeneic tumors was impaired, suggesting a key role of CD8α+ dendritic cells and cross-presentation in responses to viruses and tumor rejection [1]. In another study, Batf3 -/- mice developed metabolic syndrome, had increased intestinal permeability, and altered microbiota, indicating that BATF3 protects against metabolic syndrome and preserves intestinal epithelial barrier by maintaining beneficial microbiota [2].
In conclusion, Batf3 is essential for the development of certain dendritic cell subsets, which are crucial for antiviral and anti-tumor immune responses. Its role in maintaining intestinal epithelial homeostasis and preventing metabolic syndrome is also significant. The Batf3 KO mouse models have been valuable in revealing these functions, providing insights into the mechanisms of immune-related diseases and metabolic disorders.
References:
1. Hildner, Kai, Edelson, Brian T, Purtha, Whitney E, Murphy, Theresa L, Murphy, Kenneth M. . Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. In Science (New York, N.Y.), 322, 1097-100. doi:10.1126/science.1164206. https://pubmed.ncbi.nlm.nih.gov/19008445/
2. Hamade, Hussein, Stamps, Jasmine T, Stamps, Dalton T, Targan, Stephan R, Michelsen, Kathrin S. 2022. BATF3 Protects Against Metabolic Syndrome and Maintains Intestinal Epithelial Homeostasis. In Frontiers in immunology, 13, 841065. doi:10.3389/fimmu.2022.841065. https://pubmed.ncbi.nlm.nih.gov/35812447/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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