C57BL/6NCya-Accslem1/Cya
Common Name
Accsl-KO
Product ID
S-KO-09760
Backgroud
C57BL/6NCya
Strain ID
KOCMP-381411-Accsl-B6N-VA
When using this mouse strain in a publication, please cite “Accsl-KO Mouse (Catalog S-KO-09760) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Accsl-KO
Strain ID
KOCMP-381411-Accsl-B6N-VA
Gene Name
Product ID
S-KO-09760
Gene Alias
Gm1967
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000099690
NCBI RefSeq
NM_001033452
Target Region
Exon 2~10
Size of Effective Region
~6.9 kb
Overview of Gene Research
Accsl is one of the genes identified as a hub gene, closely related to the occurrence and development of diffuse large B-cell lymphoma (DLBCL). Through gene expression and network perturbation analysis of DLBCL patients at different clinical stages, it was found to be among the key genes associated with this disease [1].
In the research on DLBCL, gene-expression-based analysis including differential expression gene identification, weighted gene correlation network analysis (WGCNA), and key driver analysis led to the discovery of Accsl as a hub gene. This indicates its potential importance in the biological processes related to DLBCL progression, such as those related to the NOD-like receptor signaling pathway, neutrophil activation, secretory granule membrane, and carboxylic acid binding [1].
In conclusion, Accsl appears to play a significant role in the development of DLBCL. The identification of Accsl as a hub gene through gene-expression-based network analysis provides insights into the biological mechanisms of DLBCL, which may contribute to the discovery of new treatment strategies for this disease.
References:
1. Xiang, Chenxi, Ni, Huimin, Wang, Zhina, Ma, Dongshen, Liu, Hui. 2021. Agent Repurposing for the Treatment of Advanced Stage Diffuse Large B-Cell Lymphoma Based on Gene Expression and Network Perturbation Analysis. In Frontiers in genetics, 12, 756784. doi:10.3389/fgene.2021.756784. https://pubmed.ncbi.nlm.nih.gov/34721544/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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