C57BL/6NCya-4930590J08Rikem1/Cya
Common Name:
4930590J08Rik-KO
Product ID:
S-KO-09806
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
4930590J08Rik-KO
Strain ID
KOCMP-381798-4930590J08Rik-B6N-VA
Gene Name
Product ID
S-KO-09806
Gene Alias
Gm1071
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
6
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-4930590J08Rikem1/Cya mice (Catalog S-KO-09806) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000205686
NCBI RefSeq
NM_198668
Target Region
Exon 5~9
Size of Effective Region
~3.1 kb
Detailed Document
Overview of Gene Research
4930590J08Rik is a testis-specifically expressed gene. Its essential function appears to be related to male reproduction, potentially through involvement in sperm energy metabolism pathways. Genetic models, such as knockout mouse models, are valuable for studying its functions [1].
In 4930590J08Rik knockout mice, there is a delay in the first wave of spermatogenesis and a reduction of cauda epididymal sperm. Knockout spermatozoa show defective acrosome reactions and decreased progressive motility, leading to impaired in vivo fertilization. Transcriptome analysis of testes indicates that most differentially expressed genes in knockout testes are associated with metabolic processes. The knockout sperm exhibit oxidative phosphorylation deficiency and rely more on increased anaerobic glycolysis to meet ATP demands [1].
In conclusion, 4930590J08Rik is crucial for male reproduction, especially in sperm energy metabolism. The 4930590J08Rik-disrupted mouse serves as a new model for understanding the pathogenesis of idiopathic male infertility, mimicking phenotypes similar to human asthenospermia and oligozoospermia [1].
References:
1. Chen, Rui, Ma, Tingbin, Du, Shiyue, Shi, Qinghua, Liu, Jing Yu. . Impaired fertility in 4930590J08Rik mutant male mice is associated with defective sperm energy metabolism. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36, e22634. doi:10.1096/fj.202200805RR. https://pubmed.ncbi.nlm.nih.gov/36331537/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen