C57BL/6NCya-Vrtnem1/Cya
Common Name:
Vrtn-KO
Product ID:
S-KO-10055
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Vrtn-KO
Strain ID
KOCMP-432677-Vrtn-B6N-VA
Gene Name
Product ID
S-KO-10055
Gene Alias
7420416P09Rik
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
12
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Vrtnem1/Cya mice (Catalog S-KO-10055) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000095551
NCBI RefSeq
NM_001033776
Target Region
Exon 2
Size of Effective Region
~2.2 kb
Detailed Document
Overview of Gene Research
Vrtn, or vertnin, is a gene with significant importance in mammalian development, especially in relation to thoracic vertebrae development. It functions as a novel DNA-binding transcription factor, localizing in the nucleus, binding to DNA genome-wide, and regulating the transcription of genes with VRTN binding motifs. It is also involved in somite segmentation via the Notch signaling pathway [1].
In mice, Vrtn-null embryos display somitogenesis defects with failed axial rotation and fewer somites at the thoracic somite stage. Half of Vrtn heterozygous mice show abnormal spinal development with fewer thoracic vertebrae and ribs compared to wild-type littermates. This reveals that Vrtn is essential for the development of thoracic vertebrae [1].
In conclusion, Vrtn is crucial for the development of thoracic vertebrae in mammals. The gene knockout models in mice have been instrumental in uncovering its role in somitogenesis and spinal development. Understanding Vrtn's function can potentially contribute to improving pork production by selecting alleles that increase the number of thoracic vertebrae and ribs [1].
References:
1. Duan, Yanyu, Zhang, Hui, Zhang, Zhen, Ren, Jun, Huang, Lusheng. 2018. VRTN is Required for the Development of Thoracic Vertebrae in Mammals. In International journal of biological sciences, 14, 667-681. doi:10.7150/ijbs.23815. https://pubmed.ncbi.nlm.nih.gov/29904281/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen