Plcxd2, phosphatidylinositol specific phospholipase C X domain containing 2, is a gene whose function is currently being explored in relation to certain disease-associated pathways. While its exact biological function remains to be fully elucidated, studies suggest it may be involved in cell-related processes given its association with pathways that impact cell behaviors [1].

In gastric cancer, lncRNA ACTA2-AS1 acts as a competing endogenous RNA (ceRNA) to bind with miR-378a-3p, antagonizing the inhibitory effect of miR-378a-3p on Plcxd2 expression. Knockdown of Plcxd2 rescues the inhibitory effect of ACTA2-AS1 overexpression on malignant behaviors of gastric cancer cells, indicating that Plcxd2 is involved in the regulation of gastric cancer cell viability, proliferation, migration, invasion, and epithelial-mesenchymal transition [1]. Additionally, a single nucleotide polymorphism (rs2399395) in Plcxd2 has been associated with altered risk of esophageal squamous cell carcinoma (ESCC) among Han Chinese populations, though the exact role of this polymorphism in relation to Plcxd2 function in ESCC development is yet to be clearly defined [2].

In conclusion, Plcxd2 appears to play a role in the development of certain cancers, specifically gastric and esophageal squamous cell carcinomas. The studies on Plcxd2 in these cancer types provide insights into its possible involvement in cell-related processes, and further research could potentially uncover more about its function and how it may be targeted for therapeutic intervention.

References:

1. Liu, Zhiping, Hu, Kaibing, Wang, Xiang, Wang, Weiping, Wu, Yindi. 2022. lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells. In Open medicine (Warsaw, Poland), 17, 266-279. doi:10.1515/med-2021-0406. https://pubmed.ncbi.nlm.nih.gov/35274046/

2. Wang, Jiru, Wang, Qiuzi, Wei, Bin, Gao, Yong, Chen, Xiaofei. 2019. Intronic polymorphisms in genes LRFN2 (rs2494938) and DNAH11 (rs2285947) are prognostic indicators of esophageal squamous cell carcinoma. In BMC medical genetics, 20, 72. doi:10.1186/s12881-019-0796-9. https://pubmed.ncbi.nlm.nih.gov/31053115/