C57BL/6NCya-Ces2hem1/Cya
Common Name:
Ces2h-KO
Product ID:
S-KO-10157
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ces2h-KO
Strain ID
KOCMP-436059-Ces2h-B6N-VA
Gene Name
Product ID
S-KO-10157
Gene Alias
Ces2; Gm5744
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Ces2hem1/Cya mice (Catalog S-KO-10157) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000172032
NCBI RefSeq
NM_001272045
Target Region
Exon 2~5
Size of Effective Region
~2.6 kb
Detailed Document
Overview of Gene Research
Ces2h is a member of the carboxylesterase 2 (Ces2/CES2) family. In mice, this gene is involved in promoting ester hydrolysis. Its enhanced expression can evoke an unusual antioxidant response in hepatocytes, which is associated with lipid degradation processes in the liver, suggesting its importance in hepatic lipid metabolism [1].
A study found that repeated oral administrations of low-dose inorganic nanoparticles, like TiO₂, Au, and NaYF₄ nanoparticles, could promote Ces2h expression in male mice. This increase in Ces2h expression enhanced ester hydrolysis, leading to lipid degradation and alleviation of liver steatosis. This process was effective in treating fatty liver in both genetic and high-fat-diet obese mice without causing observed adverse effects [1].
In conclusion, Ces2h plays a crucial role in promoting antioxidant hepatic lipid metabolism. The findings from in vivo studies using mice models suggest that enhancing Ces2h expression through low-dose nanoparticle administration could be a promising treatment for specific hepatic metabolic disorders such as fatty liver [1].
References:
1. Cai, Jie, Peng, Jie, Feng, Juan, Deng, Renren, Wang, Diming. 2023. Antioxidant hepatic lipid metabolism can be promoted by orally administered inorganic nanoparticles. In Nature communications, 14, 3643. doi:10.1038/s41467-023-39423-3. https://pubmed.ncbi.nlm.nih.gov/37339977/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen