C57BL/6JCya-Taar3em1/Cya
Common Name:
Taar3-KO
Product ID:
S-KO-10173
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Taar3-KO
Strain ID
KOCMP-493809-Taar3-B6J-VA
Gene Name
Product ID
S-KO-10173
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Taar3em1/Cya mice (Catalog S-KO-10173) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000045152
NCBI RefSeq
NM_001008429
Target Region
Exon 1
Size of Effective Region
~2.2 kb
Detailed Document
Overview of Gene Research
Taar3, a member of the trace amine-associated receptor (TAAR) family, is involved in chemosensory functions, particularly in the detection of volatile amines. It belongs to the seven-transmembrane spanning G-protein-coupled receptor family within the rhodopsin superfamily. In rodents, it is a functional gene, while in some humans, it seems to be a pseudogene [1].
In mice, Taar3 has been shown to be involved in several biological processes. A urinary volatile amine, isobutylamine (IBA), was identified as a potent ligand for Taar3. When Taar3-expressing male mice were exposed to IBA, brain regions associated with sexual behaviors were activated, and they spent more time sniffing female urine compared to Taar2-9-/-mice (lacking all TAARs expressed in the olfactory epithelium). This indicates Taar3's role in the recognition of breeding partners and mate choice [3]. Also, in the context of diabetic nephropathy in Wistar rats, the expression of Taar3 in the kidney was altered, suggesting its potential involvement in the development of this disease [2].
In conclusion, Taar3 plays a role in chemosensory-related mate choice in mice and may be associated with the development of diabetic nephropathy in rats. The study of Taar3 using mouse models has provided insights into its functions in these specific biological and disease-related processes.
References:
1. Maguire, Janet J, Parker, William A E, Foord, Steven M, Neubig, Richard R, Davenport, Anthony P. . International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. In Pharmacological reviews, 61, 1-8. doi:10.1124/pr.109.001107. https://pubmed.ncbi.nlm.nih.gov/19325074/
2. Ruiz-Hernández, A, Cabrera-Becerra, S, Vera-Juárez, G, Arauz, J, Villafaña, S. 2020. Diabetic nephropathy produces alterations in the tissue expression profile of the orphan receptors GPR149, GPR153, GPR176, TAAR3, TAAR5 and TAAR9 in Wistar rats. In Nucleosides, nucleotides & nucleic acids, 39, 1150-1161. doi:10.1080/15257770.2020.1780437. https://pubmed.ncbi.nlm.nih.gov/32643557/
3. Harmeier, Anja, Meyer, Claas A, Staempfli, Andreas, Höner, Oliver P, Hoener, Marius C. 2018. How Female Mice Attract Males: A Urinary Volatile Amine Activates a Trace Amine-Associated Receptor That Induces Male Sexual Interest. In Frontiers in pharmacology, 9, 924. doi:10.3389/fphar.2018.00924. https://pubmed.ncbi.nlm.nih.gov/30158871/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen