C57BL/6JCya-Olig1em1/Cya
Common Name:
Olig1-KO
Product ID:
S-KO-10249
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Olig1-KO
Strain ID
KOCMP-50914-Olig1-B6J-VA
Gene Name
Product ID
S-KO-10249
Gene Alias
Bhlhb6; Olg-1; Oligo1; bHLHe21
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
16
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Olig1em1/Cya mice (Catalog S-KO-10249) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000056882
NCBI RefSeq
NM_016968
Target Region
Exon 1
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Olig1, short for oligodendrocyte transcription factor 1, is a basic helix-loop-helix transcription factor crucial for oligodendrocyte development and myelination [2,3,5]. It is involved in pathways regulating neural cell differentiation and may interact with other factors like Sox10 to drive myelin basic protein transcription [6]. Olig1 is of great biological importance as it impacts neural cell generation and maturation during development [4]. Genetic models, especially KO/CKO mouse models, are valuable for studying its functions.
In Olig1-null neonatal mice, there was significant hypomyelination after moderate neonatal stroke, and damaged white matter tracts lacked Olig2+ oligodendrocyte precursor cells (OPCs), replaced by proliferating neuronal precursors and GABAergic interneurons, indicating that Olig1 is required for noggin-induced neonatal myelin repair [1]. In Olig1-null mice, oligodendrocyte progenitor cell commitment and oligodendrocyte differentiation were impaired in the corpus callosum, resulting in hypomyelination throughout adulthood in the brain, highlighting its role in promoting oligodendrocyte progenitor cell commitment, differentiation, and myelination in the brain [5].
In conclusion, Olig1 is essential for oligodendrocyte development, differentiation, and myelination, especially in the brain. The use of Olig1 KO/CKO mouse models has revealed its critical role in neonatal myelin repair and brain myelination processes, providing insights into related neurological diseases such as neonatal white matter injury [1,5].
References:
1. Sabo, Jennifer K, Heine, Vivi, Silbereis, John C, Levison, Steven W, Rowitch, David H. . Olig1 is required for noggin-induced neonatal myelin repair. In Annals of neurology, 81, 560-571. doi:10.1002/ana.24907. https://pubmed.ncbi.nlm.nih.gov/28253550/
2. Dai, Jinxiang, Bercury, Kathryn K, Jin, Weilin, Macklin, Wendy B. . Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development. In The Journal of neuroscience : the official journal of the Society for Neuroscience, 35, 15875-93. doi:10.1523/JNEUROSCI.0882-15.2015. https://pubmed.ncbi.nlm.nih.gov/26631469/
3. Meijer, Dimphna H, Kane, Michael F, Mehta, Shwetal, Stiles, Charles D, Rowitch, David H. . Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2. In Nature reviews. Neuroscience, 13, 819-31. doi:10.1038/nrn3386. https://pubmed.ncbi.nlm.nih.gov/23165259/
4. Qi, Qi, Zhang, Yuxin, Shen, Lin, Lü, Hezuo, Hu, Jianguo. 2016. Olig1 expression pattern in neural cells during rat spinal cord development. In Neuropsychiatric disease and treatment, 12, 909-16. doi:10.2147/NDT.S99257. https://pubmed.ncbi.nlm.nih.gov/27143892/
5. Dai, Jinxiang, Bercury, Kathryn K, Ahrendsen, Jared T, Macklin, Wendy B. . Olig1 function is required for oligodendrocyte differentiation in the mouse brain. In The Journal of neuroscience : the official journal of the Society for Neuroscience, 35, 4386-402. doi:10.1523/JNEUROSCI.4962-14.2015. https://pubmed.ncbi.nlm.nih.gov/25762682/
6. Li, Huiliang, Lu, Yan, Smith, Hazel K, Richardson, William D. . Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes. In The Journal of neuroscience : the official journal of the Society for Neuroscience, 27, 14375-82. doi:. https://pubmed.ncbi.nlm.nih.gov/18160645/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen