C57BL/6JCya-Trmt10cem1/Cya
Common Name:
Trmt10c-KO
Product ID:
S-KO-10331
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Trmt10c-KO
Strain ID
KOCMP-52575-Trmt10c-B6J-VA
Gene Name
Product ID
S-KO-10331
Gene Alias
1300018J16Rik; D16Ertd454e; Rg9mtd1; Rnmtd1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
16
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Trmt10cem1/Cya mice (Catalog S-KO-10331) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000059052
NCBI RefSeq
NM_029092
Target Region
Exon 2
Size of Effective Region
~3.4 kb
Detailed Document
Overview of Gene Research
Trmt10c, also known as tRNA methyltransferase 10C, is a key enzyme involved in RNA modification. It can install N1-methyladenosine (m1A) in RNAs [2]. m1A modification is a post-transcriptional modification that regulates various biological functions, including cell invasion, proliferation, and cell-cycle regulation in cancer [2]. It is also associated with mitochondrial pre-tRNA maturation, compensating for pre-tRNA structural alterations to present it to maturation enzymes [4].
In multiple cancers, Trmt10c has been under intense study. In lung cancer, TRMT10C-mediated m7G modification of circFAM126A inhibits cancer growth by regulating cellular glycolysis [1]. In hepatoblastoma, four polymorphisms in the TRMT10C gene were significantly associated with an increased risk of the disease in Chinese children, indicating its potential role in cancer predisposition [3]. In gynecological cancers, high expression of TRMT10C is related to poorer survival, and silencing it suppresses the proliferation, colony formation, and migration of ovarian and cervical cancer cells [5].
In conclusion, Trmt10c is crucial for RNA modification, especially in the context of m1A and m7G modifications, and is involved in important biological processes. Its role in cancer, including lung cancer, hepatoblastoma, and gynecological cancers, highlights its significance in disease-related research. Studies on Trmt10c provide insights into the molecular mechanisms of cancer development and may offer potential therapeutic targets for these diseases.
References:
1. Zhao, Qingyun, Li, Xiaofei, Wu, Jiaxi, Li, Gang, Nan, Aruo. 2024. TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis. In Cell biology and toxicology, 40, 78. doi:10.1007/s10565-024-09918-w. https://pubmed.ncbi.nlm.nih.gov/39289194/
2. Liu, Yafeng, Zhang, Shujun, Gao, Xiaohui, Gu, Xinyu, Hu, Xinjun. 2024. Research progress of N1-methyladenosine RNA modification in cancer. In Cell communication and signaling : CCS, 22, 79. doi:10.1186/s12964-023-01401-z. https://pubmed.ncbi.nlm.nih.gov/38291517/
3. Liu, Yanfei, Zhu, Jinhong, Wang, Xianqiang, He, Jing, Bian, Jun. 2024. TRMT10C gene polymorphisms confer hepatoblastoma susceptibility: evidence from a seven-center case-control study. In Journal of Cancer, 15, 5396-5402. doi:10.7150/jca.98555. https://pubmed.ncbi.nlm.nih.gov/39247598/
4. Sikarwar, Juhi, Meynier, Vincent, Tisné, Carine. 2025. Advances in Human Pre-tRNA Maturation: TRMT10C and ELAC2 in Focus. In Journal of molecular biology, , 168989. doi:10.1016/j.jmb.2025.168989. https://pubmed.ncbi.nlm.nih.gov/39938738/
5. Wang, Qingying, Zhang, Qinyi, Huang, Yanjuan, Zhang, Jiawen. 2020. m1A Regulator TRMT10C Predicts Poorer Survival and Contributes to Malignant Behavior in Gynecological Cancers. In DNA and cell biology, 39, 1767-1778. doi:10.1089/dna.2020.5624. https://pubmed.ncbi.nlm.nih.gov/32833542/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen