Cpsf4l, whose specific function, common aliases, associated pathways, and overall biological importance are not yet elaborated in the provided references. However, it has been associated with several conditions through genetic analyses.

In a study on acne vulgaris, Cpsf4l was among six genes identified through SNP annotation of instrumental variables of gut microbiota and acne vulgaris, suggesting a potential genetic link between acne vulgaris patients and gut microbiota [1]. In an epigenome-wide association study of obesity-related traits, CpGs at Cpsf4l were associated with waist circumference, providing insights into the mechanisms underlying obesity-related traits [2]. Also, in a gene-excessive sleepiness interaction analysis for obstructive sleep apnea (OSA), Cpsf4l was identified as one of the genetic targets showing interaction with excessive daytime sleepiness in males, which may be related to potential therapeutic considerations for excessively sleepy OSA patients [3].

In conclusion, Cpsf4l seems to be involved in multiple disease-related processes including acne vulgaris, obesity-related traits, and a subtype of OSA. Although the exact mechanisms are not clear from the references, these associations suggest its importance in understanding the genetic basis of these conditions, potentially guiding future research in disease prevention and treatment.

References:

1. Wu, Yujia, Wang, Xiaoyun, Wu, Wenjuan, Yang, Jiankang. 2024. Mendelian randomization analysis reveals an independent causal relationship between four gut microbes and acne vulgaris. In Frontiers in microbiology, 15, 1326339. doi:10.3389/fmicb.2024.1326339. https://pubmed.ncbi.nlm.nih.gov/38371936/

2. Dhana, Klodian, Braun, Kim V E, Nano, Jana, Franco, Oscar H, Dehghan, Abbas. . An Epigenome-Wide Association Study of Obesity-Related Traits. In American journal of epidemiology, 187, 1662-1669. doi:10.1093/aje/kwy025. https://pubmed.ncbi.nlm.nih.gov/29762635/

3. Nagarajan, Pavithra, Kurniansyah, Nuzulul, Lee, Jiwon, Redline, Susan, Wang, Heming. 2024. Gene-Excessive Sleepiness Interactions Suggest Treatment Targets for Obstructive Sleep Apnea Subtype. In medRxiv : the preprint server for health sciences, , . doi:10.1101/2024.10.25.24316158. https://pubmed.ncbi.nlm.nih.gov/39574859/