C57BL/6NCya-Ccl26em1/Cya
Common Name
Ccl26-KO
Product ID
S-KO-10464
Backgroud
C57BL/6NCya
Strain ID
KOCMP-541307-Ccl26-B6N-VA
Status
When using this mouse strain in a publication, please cite “Ccl26-KO Mouse (Catalog S-KO-10464) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ccl26-KO
Strain ID
KOCMP-541307-Ccl26-B6N-VA
Gene Name
Product ID
S-KO-10464
Gene Alias
Ccl26l
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 5
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000094226
NCBI RefSeq
NM_001013412
Target Region
Exon 1~3
Size of Effective Region
~3.1 kb
Overview of Gene Research
Ccl26, also known as eotaxin-3, is a member of the eotaxin family. It functions as an eosinophil-selective chemoattractant by interacting exclusively with chemokine receptor 3 (CCR3) [3]. Ccl26 is involved in multiple biological processes such as inflammation and cell migration, and is associated with pathways like the epithelial-mesenchymal transition (EMT) pathway [1].
In a conditional Ccl26 knockout mouse model, depletion of Ccl26 in airway epithelial cells delays the resolution of allergic lung inflammation, indicating that the CCL26-CX3CR1 pathway is pivotal in resolving eosinophilic allergic lung inflammation [2]. In colon cancer cells, Ccl26 siRNAs (a form of loss-of-function) markedly reduced cell viability, proliferation, migration and invasion, accelerated apoptosis, enhanced E-cadherin expression, and reduced N-cadherin and vimentin expression, suggesting that Ccl26 promotes colon cancer progression through regulation of the EMT signaling pathway [1].
In summary, Ccl26 plays a crucial role in inflammation-related processes and cancer progression. The use of gene knockout models, such as the conditional Ccl26 knockout mouse, has been instrumental in revealing its functions in allergic lung inflammation and colon cancer, providing potential therapeutic targets for these diseases.
References:
1. Sun, Aitao, Li, YunHua, Jiang, Xiaodong. 2022. CCL26 silence represses colon cancer by inhibiting the EMT signaling pathway. In Tissue & cell, 79, 101937. doi:10.1016/j.tice.2022.101937. https://pubmed.ncbi.nlm.nih.gov/36156375/
2. Moon, Hyung-Geun, Kim, Seung-Jae, Kim, Ki-Hyun, You, Sungyoung, Park, Gye Young. . CX3CR1+ Macrophage Facilitates the Resolution of Allergic Lung Inflammation via Interacting CCL26. In American journal of respiratory and critical care medicine, 207, 1451-1463. doi:10.1164/rccm.202209-1670OC. https://pubmed.ncbi.nlm.nih.gov/36790376/
3. Shou, Jifei, Peng, Jing, Zhao, Zhikang, Xing, Yanmeng, Liu, Hongbo. 2019. CCL26 and CCR3 are associated with the acute inflammatory response in the CNS in experimental autoimmune encephalomyelitis. In Journal of neuroimmunology, 333, 576967. doi:10.1016/j.jneuroim.2019.576967. https://pubmed.ncbi.nlm.nih.gov/31151084/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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