C57BL/6JCya-Pbsnem1/Cya
Common Name
Pbsn-KO
Product ID
S-KO-10484
Backgroud
C57BL/6JCya
Strain ID
KOCMP-54192-Pbsn-B6J-VA
When using this mouse strain in a publication, please cite “Pbsn-KO Mouse (Catalog S-KO-10484) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Pbsn-KO
Strain ID
KOCMP-54192-Pbsn-B6J-VA
Gene Name
Product ID
S-KO-10484
Gene Alias
PB, Prbs
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000000003
NCBI RefSeq
NM_017471
Target Region
Exon 2~5
Size of Effective Region
~5.6 kb
Overview of Gene Research
Pbsn, often associated with prostate-related biology, is expressed in a large population of differentiated cells in the mouse prostate, along with Nkx3.1 [1]. Although its exact function is not fully detailed in the provided references, its expression pattern indicates its potential importance in the normal functioning and differentiation processes within the prostate gland. The genes in this context may be related to pathways involved in prostate cell maintenance and regeneration.
In the study of prostate cancer, the transgenic mouse models like TRAMP/Pbsn-Myc were used. The RBM22 levels were found to be down-regulated in prostate cancer (PCa) samples, and a gradual reduction of RBM22 from non-tumor to poorly differentiated PCa samples was observed in these models. RBM22 overexpression decreased aggressiveness features in vitro and in vivo, which may imply an indirect relationship between Pbsn (through the model) and PCa pathophysiology [2].
In conclusion, Pbsn is likely to be involved in the normal differentiation and function of prostate cells. The use of transgenic mouse models such as TRAMP/Pbsn-Myc has provided insights into its possible connection with prostate cancer development, suggesting that further research on Pbsn could potentially lead to a better understanding of prostate cancer mechanisms and new treatment strategies.
References:
1. Karthaus, Wouter R, Hofree, Matan, Choi, Danielle, Regev, Aviv, Sawyers, Charles L. . Regenerative potential of prostate luminal cells revealed by single-cell analysis. In Science (New York, N.Y.), 368, 497-505. doi:10.1126/science.aay0267. https://pubmed.ncbi.nlm.nih.gov/32355025/
2. Jiménez-Vacas, Juan M, Montero-Hidalgo, Antonio J, Gómez-Gómez, Enrique, Gahete, Manuel D, Luque, Raul M. 2022. Tumor suppressor role of RBM22 in prostate cancer acting as a dual-factor regulating alternative splicing and transcription of key oncogenic genes. In Translational research : the journal of laboratory and clinical medicine, 253, 68-79. doi:10.1016/j.trsl.2022.08.016. https://pubmed.ncbi.nlm.nih.gov/36089245/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.