C57BL/6JCya-Tyk2em1/Cya
Common Name:
Tyk2-KO
Product ID:
S-KO-10642
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Tyk2-KO
Strain ID
KOCMP-54721-Tyk2-B6J-VA
Gene Name
Product ID
S-KO-10642
Gene Alias
JTK1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tyk2em1/Cya mice (Catalog S-KO-10642) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000001036
NCBI RefSeq
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Target Region
Exon 2~7
Size of Effective Region
~7.3 kb
Detailed Document
Overview of Gene Research
Tyk2, short for Tyrosine kinase 2, is a member of the Janus kinase (Jak) family of intracellular signalling molecules. It participates in the Jak/signal transducer and activating protein (STAT) pathways, mediating the intracellular signaling of cytokines in numerous cellular processes, and is crucial for physiologic and inflammatory cascades [1,3]. Gene-targeted mice and hereditary defects of Tyk2 in humans have helped establish its biological and pathological functions in innate and adaptive immune responses to infection, cancer, and (auto-)inflammation [4].
Genetic linkage has associated Tyk2 dysfunction with protection from psoriasis and other immune-mediated inflammatory diseases (IMIDs) without increasing the risk of serious infections [1]. A loss-of-function missense variant in the Tyk2 gene has been used as a genetic instrument in Mendelian randomization studies, which found that genetically-proxied Tyk2 inhibition is associated with a lower risk of various autoimmune diseases [2]. In NF1-associated malignant peripheral nerve sheath tumors, overexpression of Tyk2 occurs, and pharmacologic Tyk2 inhibition dose-dependently decreases cell proliferation and induces apoptosis [5].
In conclusion, Tyk2 is essential for cytokine-mediated intracellular signaling and immune-related processes. Studies using gene-targeted mice and genetic variants as tools have revealed its role in autoimmune diseases, psoriasis, and certain tumors. These findings suggest Tyk2 as a promising therapeutic target for these disease areas.
References:
1. Rusiñol, Lluís, Puig, Luis. 2023. Tyk2 Targeting in Immune-Mediated Inflammatory Diseases. In International journal of molecular sciences, 24, . doi:10.3390/ijms24043391. https://pubmed.ncbi.nlm.nih.gov/36834806/
2. Yuan, Shuai, Wang, Lijuan, Zhang, Han, Larsson, Susanna C, Li, Xue. 2023. Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases. In EBioMedicine, 89, 104488. doi:10.1016/j.ebiom.2023.104488. https://pubmed.ncbi.nlm.nih.gov/36842216/
3. Morand, Eric, Merola, Joseph F, Tanaka, Yoshiya, Gladman, Dafna, Fleischmann, Roy. 2024. TYK2: an emerging therapeutic target in rheumatic disease. In Nature reviews. Rheumatology, 20, 232-240. doi:10.1038/s41584-024-01093-w. https://pubmed.ncbi.nlm.nih.gov/38467779/
4. Karjalainen, Anzhelika, Shoebridge, Stephen, Krunic, Milica, Strobl, Birgit, Müller, Mathias. 2020. TYK2 in Tumor Immunosurveillance. In Cancers, 12, . doi:10.3390/cancers12010150. https://pubmed.ncbi.nlm.nih.gov/31936322/
5. Borcherding, Dana C, Amin, Neha V, He, Kevin, Widemann, Brigitte C, Hirbe, Angela C. . MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors. In Clinical cancer research : an official journal of the American Association for Cancer Research, 29, 1592-1604. doi:10.1158/1078-0432.CCR-22-3722. https://pubmed.ncbi.nlm.nih.gov/36799629/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen