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C57BL/6JCya-Apomem1/Cya
Common Name:
Apom-KO
Product ID:
S-KO-10654
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Apom-KO
Strain ID
KOCMP-55938-Apom-B6J-VA
Gene Name
Apom
Product ID
S-KO-10654
Gene Alias
1190010O19Rik; G3a; NG20
Background
C57BL/6JCya
NCBI ID
55938
Modification
Conventional knockout
Chromosome
17
Phenotype
MGI:1930124
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Apomem1/Cya mice (Catalog S-KO-10654) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000025249
NCBI RefSeq
NM_018816
Target Region
Exon 2~5
Size of Effective Region
~1.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
ApoM, short for apolipoprotein M, is a member of the apolipoprotein family. It is primarily expressed and secreted from the liver and kidneys. ApoM serves as the main chaperone of sphingosine-1-phosphate (S1P), a small signalling molecule involved in numerous physiologic and pathophysiologic processes. Together, the apoM-S1P axis is associated with lipid metabolism, inflammation, endothelial cell permeability, and lipid turnover [1,2].

ApoM-deficient mice display an increased activity in brown adipose tissue and a concomitant fast turnover of triglycerides, suggesting that the apoM/S1P axis plays a significant role in maintaining a balanced triglyceride metabolism [5]. In type 1 diabetes, higher apoM levels at certain time-points in the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) cohort were associated with an increased risk of progression to macroalbuminuria (MA) and chronic kidney disease (CKD), indicating its role in the development of nephropathy [4]. In kidney renal clear cell carcinoma (KIRC), ApoM overexpression significantly inhibited cell proliferation in vitro, suppressed epithelial-mesenchymal transition (EMT), decreased metastatic capacity, and inhibited tumor growth in vivo, potentially through the Hippo-YAP signaling pathway [3].

In conclusion, ApoM is crucial for the transport of S1P and is involved in multiple biological processes. Studies using gene-knockout or other loss-of-function models have revealed its significance in lipid metabolism, diabetes-related kidney diseases, and KIRC. These findings provide insights into potential therapeutic targets for diseases associated with ApoM dysregulation.

References:

1. Chen, Zhiyang, Hu, Min. 2020. The apoM-S1P axis in hepatic diseases. In Clinica chimica acta; international journal of clinical chemistry, 511, 235-242. doi:10.1016/j.cca.2020.10.023. https://pubmed.ncbi.nlm.nih.gov/33096030/

2. Bisgaard, Line S, Christoffersen, Christina. 2021. The apoM/S1P Complex-A Mediator in Kidney Biology and Disease? In Frontiers in medicine, 8, 754490. doi:10.3389/fmed.2021.754490. https://pubmed.ncbi.nlm.nih.gov/34722589/

3. Xu, Ting, Wei, Dan, Yang, Zhe, Xu, Zhipeng, Wang, Jianning. 2023. ApoM suppresses kidney renal clear cell carcinoma growth and metastasis via the Hippo-YAP signaling pathway. In Archives of biochemistry and biophysics, 743, 109642. doi:10.1016/j.abb.2023.109642. https://pubmed.ncbi.nlm.nih.gov/37211224/

4. Baker, Nathaniel L, Hammad, Samar M, Hunt, Kelly J, Klein, Richard L, Lopes-Virella, Maria F. . Plasma apoM Levels and Progression to Kidney Dysfunction in Patients With Type 1 Diabetes. In Diabetes, 71, 1795-1799. doi:10.2337/db21-0920. https://pubmed.ncbi.nlm.nih.gov/35554520/

5. Hajny, Stefan, Borup, Anna, Elsøe, Sara, Christoffersen, Christina. 2021. Increased plasma apoM levels impair triglyceride turnover in mice. In Biochimica et biophysica acta. Molecular and cell biology of lipids, 1866, 158969. doi:10.1016/j.bbalip.2021.158969. https://pubmed.ncbi.nlm.nih.gov/34051379/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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