C57BL/6JCya-Naa10em1/Cya
Common Name:
Naa10-KO
Product ID:
S-KO-10755
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Naa10-KO
Strain ID
KOCMP-56292-Naa10-B6J-VA
Gene Name
Product ID
S-KO-10755
Gene Alias
2310039H09Rik; Ard1; Ard1a; Te2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
X
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Naa10em1/Cya mice (Catalog S-KO-10755) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000114389
NCBI RefSeq
NM_001177965
Target Region
Exon 2~3
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Naa10, also known as N-α -acetyltransferase 10, is the catalytic subunit of the N-terminal acetyltransferase A (NatA) complex. It acetylates both N-terminal amino acid and internal lysine residues of proteins, playing a crucial role in multiple biological processes such as cell proliferation, migration, differentiation, apoptosis, and autophagy. Naa10-related pathways are involved in protein Nt-acetylation, which affects about 80% of cytosolic proteins in humans [1,3].
Genetic variations in Naa10 are associated with an X-linked Naa10-related syndrome. This syndrome has a broad phenotypic spectrum including variable levels of intellectual disability, delayed milestones, autism spectrum disorder, craniofacial dysmorphology, cardiac anomalies, seizures, and visual abnormalities. Females with the p.Arg83Cys missense in Naa10 have substantial impairment, while frameshift variants toward the C-terminal end have less impact on overall functioning [1,2]. Additionally, Naa10 is overexpressed in various cancers like liver, bone, lung, breast, colon, and prostate cancers, correlating with vascular invasion, metastasis, and influencing cancer patients' survival rates and disease recurrence [3].
In conclusion, Naa10 is essential for protein acetylation and involved in diverse biological processes. Studies of Naa10-related genetic variations in humans have revealed its significance in neurodevelopmental syndromes. Its overexpression in cancer highlights its potential as a biomarker for cancer prognosis. These findings from human-based research models contribute to understanding the role of Naa10 in specific disease areas such as neurodevelopmental disorders and cancer [1-3].
References:
1. Lyon, Gholson J, Vedaie, Marall, Beisheim, Travis, Marmorstein, Ronen, Herr-Israel, Ellen. 2023. Expanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome. In European journal of human genetics : EJHG, 31, 824-833. doi:10.1038/s41431-023-01368-y. https://pubmed.ncbi.nlm.nih.gov/37130971/
2. Wu, Yiyang, Lyon, Gholson J. 2018. NAA10-related syndrome. In Experimental & molecular medicine, 50, 1-10. doi:10.1038/s12276-018-0098-x. https://pubmed.ncbi.nlm.nih.gov/30054457/
3. Kim, Sun Myung, Ha, Eunyoung, Kim, Jinyoung, Shin, So-Jin, Seo, Ji Hae. 2020. NAA10 as a New Prognostic Marker for Cancer Progression. In International journal of molecular sciences, 21, . doi:10.3390/ijms21218010. https://pubmed.ncbi.nlm.nih.gov/33126484/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen