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C57BL/6NCya-Adam21em1/Cya
Common Name:
Adam21-KO
Product ID:
S-KO-10889
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Adam21-KO
Strain ID
KOCMP-56622-Adam21-B6N-VA
Gene Name
Adam21
Product ID
S-KO-10889
Gene Alias
Adam31
Background
C57BL/6NCya
NCBI ID
56622
Modification
Conventional knockout
Chromosome
12
Phenotype
MGI:1861229
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Adam21em1/Cya mice (Catalog S-KO-10889) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000008582
NCBI RefSeq
NM_020330
Target Region
Exon 2
Size of Effective Region
~2.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Adam21, a member of the disintegrin and metalloprotease (ADAM) family of transmembrane proteins, has been implicated in multiple biological processes. ADAMs are involved in diverse functions such as cleaving cell-surface proteins, cell adhesion, and intracellular signaling [2]. Adam21 may play a role in neural regenerative processes upon neuronal injury, and is also potentially associated with cell motility and metastasis [2,3].

Using the Nuclease technology system, Adam21-null mice were generated to explore its role in male reproduction. The study found that male mice lacking Adam21 had normal fertility, with no detectable defects in spermatogenesis, sperm motility, meiotic progression, or Sertoli and Leydig cells. This suggests that Adam21 might not be essential for male fertility in mice [1].

In hepatocellular carcinoma, knockdown of ADAM21 in the KYN-2 cell line reduced invasion, migration, proliferation, and metastasis. In clinical specimens, ADAM21 positivity was associated with vascular invasion, large tumor size, high histological grade, and lower survival rates, indicating its role in HCC metastasis and its potential as a prognostic marker [3].

In conclusion, while Adam21 does not seem to be essential for male fertility in mice, it may play a role in cancer metastasis, especially in hepatocellular carcinoma. The use of Adam21-null mouse models has provided insights into its non-essential role in male reproductive processes, and further research could potentially uncover more about its functions in disease-related cell motility and metastasis [1,3].

References:

1. Chen, Yinghong, Liu, Chao, Shang, Yongliang, Li, Wei, Li, Guoping. 2021. Adam21 is dispensable for reproductive processes in mice. In PeerJ, 9, e12210. doi:10.7717/peerj.12210. https://pubmed.ncbi.nlm.nih.gov/34631320/

2. Hsia, Hung-En, Tüshaus, Johanna, Brummer, Tobias, Scilabra, Simone D, Lichtenthaler, Stefan F. 2019. Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system. In Cellular and molecular life sciences : CMLS, 76, 3055-3081. doi:10.1007/s00018-019-03173-7. https://pubmed.ncbi.nlm.nih.gov/31236626/

3. Honda, Hiroki, Takamura, Masaaki, Yamagiwa, Satoshi, Aoyagi, Yutaka, Terai, Shuji. 2017. Overexpression of a disintegrin and metalloproteinase 21 is associated with motility, metastasis, and poor prognosis in hepatocellular carcinoma. In Scientific reports, 7, 15485. doi:10.1038/s41598-017-15800-z. https://pubmed.ncbi.nlm.nih.gov/29138461/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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