C57BL/6JCya-Bcamem1/Cya
Common Name:
Bcam-KO
Product ID:
S-KO-10999
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Bcam-KO
Strain ID
KOCMP-57278-Bcam-B6J-VA
Gene Name
Product ID
S-KO-10999
Gene Alias
1200005K12Rik; B-CAM; Gplu; Lu
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Bcamem1/Cya mice (Catalog S-KO-10999) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000003061
NCBI RefSeq
NM_020486
Target Region
Exon 2~7
Size of Effective Region
~3.9 kb
Detailed Document
Overview of Gene Research
BCAM, also known as basal cell adhesion molecule, is a receptor for laminin subunit α5 and plays crucial roles in various biological processes. It is involved in cell adhesion, migration, and differentiation, and is associated with multiple signaling pathways such as PIK3R6/p-STAT3 [1]. BCAM is important in normal physiological functions like corneal epithelial differentiation and may have implications in the pathogenesis of numerous diseases including preeclampsia, various cancers, and potentially HIV-related atherosclerosis [2,4-7].
In preeclampsia, BCAM deficiency induced by adenovirus-mediated BCAM shRNA in pregnant rats led to a preeclampsia-like phenotype. BCAM knockdown in HTR-8/SVneo and JAR cells inhibited trophoblast proliferation, migration, and invasion, suppressing phosphorylation of STAT3 via down-regulation of PIK3R6 [1]. In gastric cancer, knockout of BCAM by the Nuclease technology system reduced the invasion and metastasis of GC cells, and depletion of BCAM inhibited GC cell migration and invasion [2].
In conclusion, BCAM is essential for processes like trophoblast function and corneal epithelial differentiation. The gene knockout models in preeclampsia and gastric cancer have revealed its role in disease-related cellular behaviors such as cell invasion and metastasis, highlighting its significance in understanding the pathogenesis of these diseases.
References:
1. Liu, Min, Liao, Lingyun, Gao, Yijie, Gao, Linbo, Zhou, Rong. 2022. BCAM Deficiency May Contribute to Preeclampsia by Suppressing the PIK3R6/p-STAT3 Signaling. In Hypertension (Dallas, Tex. : 1979), 79, 2830-2842. doi:10.1161/HYPERTENSIONAHA.122.20085. https://pubmed.ncbi.nlm.nih.gov/36252138/
2. Jin, Juan, Xie, Shanshan, Sun, Qiang, Zhuo, Wei, Zhou, Tianhua. 2020. Upregulation of BCAM and its sense lncRNA BAN are associated with gastric cancer metastasis and poor prognosis. In Molecular oncology, 14, 829-845. doi:10.1002/1878-0261.12638. https://pubmed.ncbi.nlm.nih.gov/31951095/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen