C57BL/6NCya-Gm6377em1/Cya
Common Name
Gm6377-KO
Product ID
S-KO-11266
Backgroud
C57BL/6NCya
Strain ID
KOCMP-622976-Gm6377-B6N-VA
Status
When using this mouse strain in a publication, please cite “Gm6377-KO Mouse (Catalog S-KO-11266) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Gm6377-KO
Strain ID
KOCMP-622976-Gm6377-B6N-VA
Gene Name
Product ID
S-KO-11266
Gene Alias
EG622976
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000060013
NCBI RefSeq
NM_001037917
Target Region
Exon 2
Size of Effective Region
~0.9 kb
Overview of Gene Research
Gm6377, also named TASL2, is involved in the TLR7/9-mediated innate immune response pathway. It plays a role in mediating IRF5-dependent antiviral responses and autoimmunity, and is thus of significance in the context of antimicrobial immunity and autoimmune conditions like systemic lupus erythematosus (SLE) [2].
In the study of multiple myeloma (MM), Gm6377 was found to have differential expression levels. B cells expressed high levels of Gm6377 mRNA, while PCs and the mus musculus myeloma SP 2/0 cells had low levels. Overexpression of Gm6377 suppressed SP 2/0 cell proliferation and tumor progression in the xenograft mouse model by reducing the activation of the Myc promoter, suggesting its potential as a therapeutic target for MM [1]. In relation to TLR7/9-mediated immune responses, double knockout of TASL and Gm6377 (TASLDKO) phenocopied SLC15A4-deficient mice, showing comparable impairment of innate and humoral responses. TASLDKO mice failed to control chronic LCMV infection but were protected in a pristane-induced SLE disease model, demonstrating the critical pathophysiological role of Gm6377 in TLR7/9-driven inflammatory responses [2].
In conclusion, Gm6377 has diverse functions. In the context of MM, it can suppress tumor cell growth by modulating Myc activation. In the immune system, it is crucial for TLR7/9-driven inflammatory responses. Studies using gene knockout models, especially in mice, have revealed its roles in these specific disease-related biological processes, providing potential therapeutic implications for MM and SLE [1,2].
References:
1. Zhai, B, Hou, C, Xu, R, Han, G, Wang, R. 2020. Gm6377 suppressed SP 2/0 xenograft tumor by down-regulating Myc transcription. In Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 22, 1463-1471. doi:10.1007/s12094-019-02280-y. https://pubmed.ncbi.nlm.nih.gov/31950438/
2. Drobek, Ales, Bernaleau, Léa, Delacrétaz, Maeva, Marquis, Julien, Rebsamen, Manuele. 2025. The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse. In Nature communications, 16, 967. doi:10.1038/s41467-024-55692-y. https://pubmed.ncbi.nlm.nih.gov/39856058/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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