C57BL/6JCya-Marchf10em1/Cya
Common Name:
Marchf10-KO
Product ID:
S-KO-11346
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Marchf10-KO
Strain ID
KOCMP-632687-Marchf10-B6J-VA
Gene Name
Product ID
S-KO-11346
Gene Alias
4933417C16Rik; March10; Rnf190
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Marchf10em1/Cya mice (Catalog S-KO-11346) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000049995
NCBI RefSeq
NM_172568.2
Target Region
Exon 5
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Marchf10, also known as MARCH10, is a gene, but specific details about its essential function, associated pathways, and overall biological importance are not explicitly provided in the given abstract. However, genes in the MARCH (membrane-associated RING-CH) family are often involved in ubiquitination processes, which play crucial roles in various cellular functions like protein degradation, signal transduction, and immune response [1].
The single-variant and burden analyses of whole-exome and whole-genome sequencing data from individuals with type 1 diabetes identified that the burden of protein-altering variants (PAVs) in Marchf10 was significantly associated with lipid phenotypes (p<2.9×10-6) [1].
In conclusion, while the exact function of Marchf10 from this study remains somewhat unclear, the association of its PAVs with lipid phenotypes suggests its potential role in lipid metabolism-related biological processes. This finding may have implications for understanding the genetic basis of lipid-related diseases, such as those associated with dyslipidemia in the context of type 1 diabetes [1].
References:
1. Sandholm, Niina, Hotakainen, Ronja, Haukka, Jani K, Forsblom, Carol, Groop, Per-Henrik. 2022. Whole-exome sequencing identifies novel protein-altering variants associated with serum apolipoprotein and lipid concentrations. In Genome medicine, 14, 132. doi:10.1186/s13073-022-01135-6. https://pubmed.ncbi.nlm.nih.gov/36419110/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen