C57BL/6JCya-Fn3kem1/Cya
Common Name
Fn3k-KO
Product ID
S-KO-11368
Backgroud
C57BL/6JCya
Strain ID
KOCMP-63828-Fn3k-B6J-VA
Status
When using this mouse strain in a publication, please cite “Fn3k-KO Mouse (Catalog S-KO-11368) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Fn3k-KO
Strain ID
KOCMP-63828-Fn3k-B6J-VA
Gene Name
Product ID
S-KO-11368
Gene Alias
2310074G21Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 11
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000026175
NCBI RefSeq
NM_022014.4
Target Region
Exon 2
Size of Effective Region
~0.8 kb
Overview of Gene Research
Fn3k, short for Fructosamine-3-kinase, is an enzyme that plays a crucial role in protein de-glycation. It mitigates excessive protein glycation by phosphorylating and destabilizing fructosamines, thus preventing the formation of irreversible advanced glycation end-products (AGEs) [2]. This function is related to multiple biological pathways, such as the NRF2-mediated redox balance pathway. NRF2 is a transcription factor controlling a cell stress program implicated in cancer, and its activity depends on Fn3k-mediated de-glycation [1].
In in vivo studies, the development of hepatocellular carcinoma triggered by MYC and Keap1 inactivation was found to depend on Fn3k [1]. This indicates that in the context of this cancer-related pathway, Fn3k is essential for the oncogenic action of NRF2. Without Fn3k, NRF2 is extensively glycated, unstable, and defective in binding to small MAF proteins and transcriptional activation [1].
In conclusion, Fn3k is a key enzyme in protein de-glycation, significantly influencing the NRF2-mediated redox balance pathway. The use of in vivo models, such as those related to hepatocellular carcinoma, has revealed its importance in cancer-associated biological processes, suggesting that Fn3k could be a potential target for cancer therapy [1].
References:
1. Sanghvi, Viraj R, Leibold, Josef, Mina, Marco, Hendrickson, Ronald C, Wendel, Hans-Guido. . The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase. In Cell, 178, 807-819.e21. doi:10.1016/j.cell.2019.07.031. https://pubmed.ncbi.nlm.nih.gov/31398338/
2. Ogidigo, Joyce, Kumari, Reena, Sanghvi, Viraj R. 2025. FN3K: the (un)sweetest kinase. In Trends in biochemical sciences, 50, 372-373. doi:10.1016/j.tibs.2025.03.009. https://pubmed.ncbi.nlm.nih.gov/40187910/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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