Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Herpud1em1/Cya
Common Name:
Herpud1-KO
Product ID:
S-KO-11404
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Herpud1-KO
Strain ID
KOCMP-64209-Herpud1-B6N-VA
Gene Name
Herpud1
Product ID
S-KO-11404
Gene Alias
Herp; Mifl; SUP
Background
C57BL/6NCya
NCBI ID
64209
Modification
Conventional knockout
Chromosome
8
Phenotype
MGI:1927406
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Herpud1em1/Cya mice (Catalog S-KO-11404) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000161576
NCBI RefSeq
NM_022331
Target Region
Exon 2~6
Size of Effective Region
~3.2 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Herpud1, also known as homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1, is an endoplasmic reticulum membrane protein involved in maintaining intracellular Ca2+ homeostasis under stress conditions. It is part of the endoplasmic reticulum-associated degradation (ERAD) complex and participates in inositol 1,4,5-trisphosphate receptor (IP3R) degradation and Ca2+ signaling [2,4]. Herpud1 is also an important early marker of endoplasmic reticulum stress (ERS) and is involved in the ubiquitination and degradation of several unfolded proteins [3].

In Herpud1-knockout mice, there is cardiac hypertrophy and dysfunction, along with elevated levels of hypertrophic markers and IP3R in cardiomyocytes, indicating Herpud1 is a negative regulator of pathological cardiac hypertrophy [4]. Herpud1 -deficient mice also display glucose intolerance without altered insulin secretion, and Herpud1 silencing in L6 myotubes decreases insulin-dependent glucose uptake, suggesting its importance in insulin-dependent glucose disposal in skeletal muscle [5]. In a mouse model of homocysteine-induced atherosclerosis, Herpud1 knockout reduces amyloid-β40 expression, inflammation, and oxidative stress, alleviating atherosclerosis via JNK/AP1 signaling inhibition [6]. Also, Herpud1 deficiency alleviates homocysteine-induced aortic valve calcification in mice, as Herpud1 silencing activates cell autophagy, inhibiting osteogenic differentiation of aortic valve interstitial cells (AVICs) [1].

In conclusion, Herpud1 plays crucial roles in multiple biological processes and disease conditions. Studies using Herpud1 knockout mouse models have revealed its significance in cardiac function, glucose metabolism, and several cardiovascular-related diseases such as cardiac hypertrophy, aortic valve calcification, and atherosclerosis. Understanding Herpud1's functions provides potential therapeutic targets for these diseases.

References:

1. Xie, Wenqing, Shan, Yue, Wu, Zhuonan, Lin, Hui, Guo, Hangyuan. 2023. Herpud1 deficiency alleviates homocysteine-induced aortic valve calcification. In Cell biology and toxicology, 39, 2665-2684. doi:10.1007/s10565-023-09794-w. https://pubmed.ncbi.nlm.nih.gov/36746840/

2. Paredes, Felipe, Navarro-Marquez, Mario, Quiroga, Clara, San Martin, Alejandra, Lavandero, Sergio. 2023. HERPUD1 governs tumor cell mitochondrial function via inositol 1,4,5-trisphosphate receptor-mediated calcium signaling. In Free radical biology & medicine, 211, 24-34. doi:10.1016/j.freeradbiomed.2023.11.022. https://pubmed.ncbi.nlm.nih.gov/38043868/

3. Nie, Xin, Liu, Dawo, Zheng, Mingjun, Zhu, Liancheng, Lin, Bei. 2022. HERPUD1 promotes ovarian cancer cell survival by sustaining autophagy and inhibit apoptosis via PI3K/AKT/mTOR and p38 MAPK signaling pathways. In BMC cancer, 22, 1338. doi:10.1186/s12885-022-10248-5. https://pubmed.ncbi.nlm.nih.gov/36544104/

4. Torrealba, Natalia, Navarro-Marquez, Mario, Garrido, Valeria, Kokame, Koichi, Lavandero, Sergio. 2017. Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation. In Scientific reports, 7, 13402. doi:10.1038/s41598-017-13797-z. https://pubmed.ncbi.nlm.nih.gov/29042597/

5. Navarro-Marquez, Mario, Torrealba, Natalia, Troncoso, Rodrigo, Kokame, Koichi, Lavandero, Sergio. 2018. Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis. In Biochimica et biophysica acta. Molecular basis of disease, 1864, 1653-1662. doi:10.1016/j.bbadis.2018.02.018. https://pubmed.ncbi.nlm.nih.gov/29486284/

6. Gao, Feidan, Zhang, Jie, Ni, Tingjuan, Guo, Hangyuan, Chi, Jufang. 2020. Herpud1 deficiency could reduce amyloid-β40 expression and thereby suppress homocysteine-induced atherosclerosis by blocking the JNK/AP1 pathway. In Journal of physiology and biochemistry, 76, 383-391. doi:10.1007/s13105-020-00741-5. https://pubmed.ncbi.nlm.nih.gov/32488540/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest