C57BL/6NCya-Lpin3em1/Cya
Common Name
Lpin3-KO
Product ID
S-KO-11449
Backgroud
C57BL/6NCya
Strain ID
KOCMP-64899-Lpin3-B6N-VA
Status
When using this mouse strain in a publication, please cite “Lpin3-KO Mouse (Catalog S-KO-11449) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Lpin3-KO
Strain ID
KOCMP-64899-Lpin3-B6N-VA
Gene Name
Product ID
S-KO-11449
Gene Alias
mKIAA4023, 9130206L11Rik
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000109456
NCBI RefSeq
NM_022883
Target Region
Exon 3~7
Size of Effective Region
~3.4 kb
Overview of Gene Research
Lpin3, encoding phosphatidate phosphatase type 1 enzyme, is involved in the de novo biosynthesis of triacylglycerol, phosphatidylcholine, and phosphatidylethanolamine [3]. Lipins, including Lpin3, also have a role in transcriptional co-regulation [2]. It is widely expressed in tissues such as liver, small intestine, kidney, and adipose tissues in sheep [2].
In colorectal cancer, LPIN3 is highly expressed and promotes tumor growth. Knockdown of LPIN3 in vivo strengthened CD8+ T cell-mediated cytotoxicity, infiltration, and activation. LPIN3 may enhance tumor growth by activating the β-catenin signaling pathway and reduce tumor antigen presentation signals, suppressing CD8+ T cell-mediated cytotoxicity [1].
In summary, Lpin3 has important functions in lipid metabolism and transcriptional co-regulation. In colorectal cancer, studies (such as LPIN3 knockdown in vivo) have revealed its role in promoting tumor growth by influencing β-catenin signaling and CD8+ T cell activity, providing insights into the molecular mechanisms of colorectal cancer progression.
References:
1. Zhang, Xiaoming, Fang, Hao, Wu, Wenliang, Wang, Haizhou, Shi, Yifei. 2025. LPIN3 promotes colorectal cancer growth by dampening intratumoral CD8+ T cell effector function. In Cancer immunology, immunotherapy : CII, 74, 135. doi:10.1007/s00262-025-03989-2. https://pubmed.ncbi.nlm.nih.gov/40042548/
2. Jiao, Xiao-Li, Jing, Jiong-Jie, Qiao, Li-Ying, Jia, Xia-Li, Liu, Wen-Zhong. 2016. Ontogenetic Expression of Lpin2 and Lpin3 Genes and Their Associations with Traits in Two Breeds of Chinese Fat-tailed Sheep. In Asian-Australasian journal of animal sciences, 29, 333-42. doi:10.5713/ajas.15.0467. https://pubmed.ncbi.nlm.nih.gov/26950863/
3. He, Xiaoping, Xu, Xuewen, Liu, Bang. 2008. Molecular characterization, chromosomal localization and association analysis with back-fat thickness of porcine LPIN2 and LPIN3. In Molecular biology reports, 36, 1819-24. doi:10.1007/s11033-008-9385-2. https://pubmed.ncbi.nlm.nih.gov/18989753/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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