C57BL/6JCya-Pglsem1/Cya
Common Name
Pgls-KO
Product ID
S-KO-11569
Backgroud
C57BL/6JCya
Strain ID
KOCMP-66171-Pgls-B6J-VA
Status
When using this mouse strain in a publication, please cite “Pgls-KO Mouse (Catalog S-KO-11569) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Pgls-KO
Strain ID
KOCMP-66171-Pgls-B6J-VA
Gene Name
Product ID
S-KO-11569
Gene Alias
Plgs, 1110030K05Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 8
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000034264
NCBI RefSeq
NM_025396
Target Region
Exon 1~5
Size of Effective Region
~4.1 kb
Overview of Gene Research
Pgls, also known as 6-phosphogluconolactonase, is likely involved in metabolic processes as it is related to 6-phosphogluconolactone metabolism. Its function may be significant in maintaining normal metabolic balance within cells, potentially participating in pathways related to glucose metabolism and energy production [1].
In a study related to gastric cancer, PglS was found to be significantly up-regulated. High expression of PglS was correlated with TNM staging in gastric cancer, and its overexpression predicted worse overall survival (OS) and post-progression survival (PPS) for gastric cancer patients, especially in male patients, those with lymph node metastasis, and Her-2 (-) patients. This indicates that PglS may play a role in the progression and prognosis of gastric cancer [1].
In conclusion, PglS appears to have an important function in metabolism, and its abnormal expression is associated with gastric cancer, as revealed through studies on human tissue samples. Understanding the role of PglS in gastric cancer can potentially provide new insights into the disease mechanism, which may contribute to early screening, prognostic monitoring, and the development of new treatment strategies for gastric cancer.
References:
1. Yuan, Xiaoxia, Xiao, Yang, Luo, Yaomin, Song, Shenjie, Jiang, Zhen. 2021. Identification and validation of PGLS as a metabolic target for early screening and prognostic monitoring of gastric cancer. In Journal of clinical laboratory analysis, 36, e24189. doi:10.1002/jcla.24189. https://pubmed.ncbi.nlm.nih.gov/34953081/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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