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C57BL/6JCya-Fam229bem1/Cya
Common Name:
Fam229b-KO
Product ID:
S-KO-11657
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Fam229b-KO
Strain ID
KOCMP-66337-Fam229b-B6J-VA
Gene Name
Fam229b
Product ID
S-KO-11657
Gene Alias
1700025K23Rik
Background
C57BL/6JCya
NCBI ID
66337
Modification
Conventional knockout
Chromosome
10
Phenotype
MGI:1913587
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fam229bem1/Cya mice (Catalog S-KO-11657) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000063204
NCBI RefSeq
NM_183254
Target Region
Exon 4~5
Size of Effective Region
~1.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Fam229b, with no common aliases mentioned, is a protein-coding gene. Its exact essential function, associated pathways, and overall biological importance are yet to be fully characterized. However, genetic models could potentially be valuable in further elucidating these aspects.

In neonatal rats, microarray analysis of odor-encoding mitral cells from pups that underwent odor preference learning revealed that the protein-coding transcription of Fam229b was up-regulated. This learning paradigm showed that memory was demonstrable at 24 h post-training, and the up-regulation of Fam229b was part of a set of gene changes consistent with extracellular matrix remodeling and ryanodine receptor involvement in odor preference learning [1].

In conclusion, through the study in neonatal rat models, Fam229b appears to be involved in the molecular processes related to odor preference learning, potentially via its role in extracellular matrix remodeling and ryanodine receptor-associated pathways. This provides a starting point for understanding its function in learning-related biological processes, although further research, perhaps including gene knockout models, could more precisely define its role in these and other potential disease-relevant areas.

References:

1. Nartey, Michaelina N, Peña-Castillo, Lourdes, LeGrow, Megan, Harley, Carolyn W, McLean, John H. 2020. Learning-induced mRNA alterations in olfactory bulb mitral cells in neonatal rats. In Learning & memory (Cold Spring Harbor, N.Y.), 27, 209-221. doi:10.1101/lm.051177.119. https://pubmed.ncbi.nlm.nih.gov/32295841/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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