C57BL/6JCya-Tnfaip8l1em1/Cya
Common Name:
Tnfaip8l1-KO
Product ID:
S-KO-11721
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Tnfaip8l1-KO
Strain ID
KOCMP-66443-Tnfaip8l1-B6J-VA
Gene Name
Product ID
S-KO-11721
Gene Alias
2600017J23Rik; TIPE1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
17
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tnfaip8l1em1/Cya mice (Catalog S-KO-11721) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000077788
NCBI RefSeq
NM_025566
Target Region
Exon 2
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Tnfaip8l1, also known as TIPE1, is a member of the TNFAIP8 gene family. It plays significant roles in various biological processes such as tumorigenesis, autophagy, and mitochondrial regulation [1,3,4]. It may be involved in pathways like "ECM-receptor interaction" based on GO and KEGG analyses [1]. Genetic models help in understanding its functions better.
In a mouse model of diabetic nephropathy, conditional knockout of Tipe1 in renal tubular epithelial cells (RTECs) decreased urine protein creatinine ratio, renal tubular damage, epithelial-mesenchymal transition, and interstitial fibrosis. Tipe1 deficiency also regulated mitochondrial function in RTECs, indicating its role in maintaining mitochondrial homeostasis [2]. In a Parkinson's disease model, OS-induced Tnfaip8l1/Oxi-β increased autophagy by competing with TSC2 to bind FBXW5, thus stabilizing TSC2 and inhibiting mTOR phosphorylation [3].
In conclusion, Tnfaip8l1 is involved in maintaining mitochondrial function and regulating autophagy, which are crucial for normal cellular function. Studies using gene knockout models in diabetes and Parkinson's disease have revealed its potential as a therapeutic target in these disease areas, providing insights into disease mechanisms and possible treatment strategies.
References:
1. Sun, Jinghui, Zhang, Xuezhong, Zhu, Bin, Chen, Yingjun, Wang, Hui. . A pan-cancer analysis of TNFAIP8L1 in human tumors. In Medicine, 102, e36291. doi:10.1097/MD.0000000000036291. https://pubmed.ncbi.nlm.nih.gov/38065896/
2. Liu, Lei, Bai, Fang, Song, Hui, Yang, Xiangdong, Liang, Xiaohong. 2022. Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy. In Redox biology, 50, 102260. doi:10.1016/j.redox.2022.102260. https://pubmed.ncbi.nlm.nih.gov/35152003/
3. Ha, Ji-Young, Kim, Ji-Soo, Kang, Young-Hee, Kim, Yoon-Seong, Son, Jin H. 2013. Tnfaip8l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model. In Journal of neurochemistry, , . doi:10.1111/j.1471-4159.2013.12643.x. https://pubmed.ncbi.nlm.nih.gov/24372178/
4. Bordoloi, Devivasha, Banik, Kishore, Shabnam, Bano, Sethi, Gautam, Kunnumakkara, Ajaikumar B. 2018. TIPE Family of Proteins and Its Implications in Different Chronic Diseases. In International journal of molecular sciences, 19, . doi:10.3390/ijms19102974. https://pubmed.ncbi.nlm.nih.gov/30274259/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen