C57BL/6JCya-Ribc1em1/Cya
Common Name:
Ribc1-KO
Product ID:
S-KO-11808
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Ribc1-KO
Strain ID
KOCMP-66611-Ribc1-B6J-VA
Gene Name
Product ID
S-KO-11808
Gene Alias
2610028I09Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
X
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ribc1em1/Cya mice (Catalog S-KO-11808) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000026288
NCBI RefSeq
NM_025660.3
Target Region
Exon 4~5
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Ribc1, short for RIB43A domain with coiled-coils 1, is a homolog protein of RIB43a. It is a microtubule inner protein (MIP) localized in the inner lumen of the doublet microtubules (DMTs) in mouse sperm flagella [1]. While its exact associated pathways are not fully clear, it is likely related to processes involved in sperm function and mammalian reproduction. Genetic models, such as knockout mice, are valuable tools for studying its function.
In a study using the Nuclease technology system to generate Ribc1 knockout (KO), Ribc2 KO, and Ribc1 and Ribc2 double-knockout (Ribc1/2 DKO) mice, it was found that the loss of either RIBC1 or RIBC2 alone did not impact male fertility. However, the absence of both RIBC1 and RIBC2 led to a decrease in pup numbers. Sperm motility analysis showed that Ribc1 KO spermatozoa had reduced velocity, and Ribc1/2 DKO sperm velocities were significantly lower than those of Ribc1 KO mice. Although no axonemal structural abnormalities were observed in Ribc1/2 DKO spermatozoa at the TEM level, both RIBC1 and RIBC2 function cooperatively in sperm motility [1].
In conclusion, Ribc1, along with RIBC2, plays a role in sperm motility, which in turn affects litter size in male mice. The study using Ribc1 KO and related mouse models has provided insights into the function of Ribc1 in mammalian reproduction, highlighting its importance in understanding the mechanisms underlying male fertility [1].
References:
1. Katsuma, Kento, Shimada, Keisuke, Tonai, Shingo, Miyata, Haruhiko, Ikawa, Masahito. 2025. The absence of both RIBC1 and RIBC2 induces decreased sperm motility and litter size in male mice. In Andrology, , . doi:10.1111/andr.70045. https://pubmed.ncbi.nlm.nih.gov/40265983/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen