Plbd1, or Phospholipase B domain-containing protein 1, is a transcription factor that regulates phospholipid metabolism [2]. It may be involved in lysosomal functions as it was identified as one of the hub lysosomal genes closely linked to psoriasis occurrence [3].

In ischemic stroke models, Plbd1 was significantly upregulated in affected brain tissues and cells. Knockdown of Plbd1 mitigated cellular injury in vitro and reversed brain damage in vivo, indicating its role in exacerbating ischemic stroke-induced brain damage. Lactylation at the K155 site of Plbd1 enhanced its expression in response to elevated lactate levels after oxygen-glucose deprivation and reperfusion treatment [1]. In glioma, high expression of Plbd1 was observed, and knockdown of it significantly inhibited the proliferation and invasive ability of glioma cells, suggesting it could be a potential tumor prognostic biomarker and immunotherapeutic target [2]. Also, in acute myocardial infarction patients, peripheral blood RNA levels of Plbd1 were new independent predictors of left ventricular dysfunction post-MI [4].

In summary, Plbd1 plays important roles in multiple disease conditions. Its upregulation via lactylation at the K155 site exacerbates ischemic stroke-induced brain damage. In glioma, it is involved in cell proliferation and invasion, and in acute myocardial infarction, it can predict left ventricular dysfunction. The study of Plbd1 using gene knockout or other loss-of-function models helps to understand its functions in these diseases, potentially providing new therapeutic strategies.

References:

1. Zhou, Faming, Chen, Guanghui, Li, Xiaoli, Yu, Xiaodong, Yang, Yinyin. . Lactylation of PLBD1 Facilitates Brain Injury Induced by Ischemic Stroke. In Journal of integrative neuroscience, 24, 25949. doi:10.31083/JIN25949. https://pubmed.ncbi.nlm.nih.gov/40018779/

2. Wei, Minghao, Zhou, Gaoyang, Chen, Lian, Gao, Li, Gao, Guodong. 2024. The prognostic and immune significance of PLBD1 in pan-cancer and its roles in proliferation and invasion of glioma. In Journal of Cancer, 15, 3857-3872. doi:10.7150/jca.96365. https://pubmed.ncbi.nlm.nih.gov/38911364/

3. Deng, Wenhui, Yan, Yijiao, Shi, Chengzhi, Sui, Daoshun. 2024. Single-cell and bulk RNAseq unveils the immune infiltration landscape and targeted therapeutic biomarkers of psoriasis. In Frontiers in genetics, 15, 1365273. doi:10.3389/fgene.2024.1365273. https://pubmed.ncbi.nlm.nih.gov/38699235/

4. Vanhaverbeke, Maarten, Vausort, Mélanie, Veltman, Denise, Janssens, Stefan, Sinnaeve, Peter R. 2019. Peripheral Blood RNA Levels of QSOX1 and PLBD1 Are New Independent Predictors of Left Ventricular Dysfunction After Acute Myocardial Infarction. In Circulation. Genomic and precision medicine, 12, e002656. doi:10.1161/CIRCGEN.119.002656. https://pubmed.ncbi.nlm.nih.gov/31756302/