C57BL/6NCya-Trim59em1/Cya
Common Name
Trim59-KO
Product ID
S-KO-12010
Backgroud
C57BL/6NCya
Strain ID
KOCMP-66949-Trim59-B6N-VA
Status
When using this mouse strain in a publication, please cite “Trim59-KO Mouse (Catalog S-KO-12010) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Trim59-KO
Strain ID
KOCMP-66949-Trim59-B6N-VA
Gene Name
Product ID
S-KO-12010
Gene Alias
Mrf1, TSBF1, 2310035M22Rik, 2700022F13Rik
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000107802
NCBI RefSeq
NM_025863
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Overview of Gene Research
TRIM59, a member of the tripartite motif containing (TRIM) protein family, functions as an E3 ubiquitin ligase through its RING domain. It is involved in development, immune response, and the invasion and metastasis of tumors, and is expressed by multiple types of cells. It participates in pathways such as the NFKB pathway and is associated with autophagy, macrophage activation, and cell proliferation-related processes [1].
Macrophage-specific TRIM59 conditional knockout (CKO) mice have revealed that TRIM59 deficiency promotes M1 macrophage activation and inhibits colorectal cancer through the STAT1 signaling pathway. TRIM59 could regulate macrophage polarization by ubiquitinating and degrading STAT1 [2].
In summary, TRIM59 is significant in immune-related processes and tumor-related events. The use of CKO mouse models has provided insights into its role in colorectal cancer, suggesting that the TRIM59/STAT1 signaling pathway may be a promising target for CRC treatment. Manipulating TRIM59 levels and activity could potentially be an avenue for treating immune diseases and tumors [1,2].
References:
1. Jin, Zheng, Chen, Tiffany, Zhu, Zhenhua, Xu, Baohui, Yan, Dongmei. 2022. The role of TRIM59 in immunity and immune-related diseases. In International reviews of immunology, 43, 33-40. doi:10.1080/08830185.2022.2102618. https://pubmed.ncbi.nlm.nih.gov/35975813/
2. Wang, Haidong, Lou, Jun, Liu, Hao, Pan, Hongming, Han, Weidong. 2024. TRIM59 deficiency promotes M1 macrophage activation and inhibits colorectal cancer through the STAT1 signaling pathway. In Scientific reports, 14, 16081. doi:10.1038/s41598-024-66388-0. https://pubmed.ncbi.nlm.nih.gov/38992114/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.