C57BL/6JCya-Cisd2em1/Cya
Common Name
Cisd2-KO
Product ID
S-KO-12048
Backgroud
C57BL/6JCya
Strain ID
KOCMP-67006-Cisd2-B6J-VA
When using this mouse strain in a publication, please cite “Cisd2-KO Mouse (Catalog S-KO-12048) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cisd2-KO
Strain ID
KOCMP-67006-Cisd2-B6J-VA
Gene Name
Product ID
S-KO-12048
Gene Alias
1500009M05Rik, 1500026J14Rik, 1500031D15Rik, B630006A20Rik, Miner1, Naf-1, Noxp70, Zcd2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000029815
NCBI RefSeq
NM_025902
Target Region
Exon 2
Size of Effective Region
~0.2 kb
Overview of Gene Research
Cisd2, also known as CDGSH iron-sulfur domain 2, is an iron-sulfur protein with a [2Fe-2S] cluster. It is crucial for cell proliferation, iron homeostasis, and maintaining cellular homeostasis, including cytosolic Ca2+ homeostasis, ER integrity, and mitochondrial function. It is associated with pathways like autophagy, p62-Keap1-NRF2, and is related to aging-related diseases, cancers, and lifespan regulation. Genetic models, such as knockout and transgenic mice, have been used to study its functions [1,2,3,4].
In Cisd2 knockout mice, Cisd2 deficiency shortens lifespan and leads to premature aging phenotypes, along with mitochondrial breakdown and dysfunction with autophagic cell death features [4]. In cancer-related studies, knockdown of Cisd2 in cells promotes ferroptosis through ferritinophagy-mediated ferritin turnover and inhibition of the p62-Keap1-NRF2 pathway [1].
In conclusion, Cisd2 is essential for multiple biological functions including lifespan regulation, cellular homeostasis, and iron metabolism. Studies using Cisd2 knockout mouse models have revealed its significance in aging-related diseases and cancer, highlighting its potential as a therapeutic target for these conditions.
References:
1. Li, Yanchun, Xu, Bing, Ren, Xueying, Wang, Ying, Du, Jing. 2022. Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62-Keap1-NRF2 pathway. In Cellular & molecular biology letters, 27, 81. doi:10.1186/s11658-022-00383-z. https://pubmed.ncbi.nlm.nih.gov/36180832/
2. Liao, Hai-Yang, Liao, Bei, Zhang, Hai-Hong. 2021. CISD2 plays a role in age-related diseases and cancer. In Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 138, 111472. doi:10.1016/j.biopha.2021.111472. https://pubmed.ncbi.nlm.nih.gov/33752060/
3. Shen, Zhao-Qing, Huang, Yi-Long, Teng, Yuan-Chi, Yeh, Chi-Hsiao, Tsai, Ting-Fen. 2021. CISD2 maintains cellular homeostasis. In Biochimica et biophysica acta. Molecular cell research, 1868, 118954. doi:10.1016/j.bbamcr.2021.118954. https://pubmed.ncbi.nlm.nih.gov/33422617/
4. Wang, C-H, Kao, C-H, Chen, Y-F, Wei, Y-H, Tsai, T-F. 2014. Cisd2 mediates lifespan: is there an interconnection among Ca²⁺ homeostasis, autophagy, and lifespan? In Free radical research, 48, 1109-14. doi:10.3109/10715762.2014.936431. https://pubmed.ncbi.nlm.nih.gov/24974737/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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