Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Ube2g1em1/Cya
Common Name:
Ube2g1-KO
Product ID:
S-KO-12125
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Ube2g1-KO
Strain ID
KOCMP-67128-Ube2g1-B6N-VA
Gene Name
Ube2g1
Product ID
S-KO-12125
Gene Alias
2700059C12Rik; D130023C12Rik
Background
C57BL/6NCya
NCBI ID
67128
Modification
Conventional knockout
Chromosome
11
Phenotype
MGI:1914378
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Ube2g1em1/Cya mice (Catalog S-KO-12125) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000021148
NCBI RefSeq
NM_025985
Target Region
Exon 3~4
Size of Effective Region
~4.9 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Ube2g1, the ubiquitin-conjugating enzyme E2G1, is a key factor in the ubiquitination process, which is closely related to the post-translation modification of proteins. Ubiquitination plays vital roles in many cellular processes such as immune defense, cell cycle regulation, and protein degradation pathways [2,3,4,5,6].

In the context of osteoarthritis (OA), circRNA-UBE2G1, which is associated with the Ube2g1 gene, was found to be upregulated in OA tissues. Function assays indicated that its inhibition could reduce the effects of LPS on C28/I2 cells viability and apoptosis, and it was shown to act via the miR-373/HIF-1a axis [1]. In large yellow croaker, the LcUbe2g1 was significantly activated by the infection of Pseudomonas plecoglossicida, and it interacted with NEDD8 to co-regulate the ubiquitination process, playing a crucial role in the immune response against this infection [2]. In multiple myeloma, UBE2G1 cooperated with UBE2D3 to promote the K48-linked polyubiquitination of CRL4CRBN neomorphic substrates. Blockade of UBE2G1 diminished the ubiquitination and degradation of these substrates and the consequent antitumor activities of tested cereblon-modulating agents, highlighting its importance in drug-induced protein degradation and potential drug resistance [3,6].

In summary, Ube2g1 is essential in ubiquitination-related biological functions. Its role in diseases such as osteoarthritis, infectious diseases in fish, and multiple myeloma has been revealed through various functional studies. Understanding Ube2g1's functions contributes to a better understanding of disease mechanisms and may provide potential therapeutic targets for these diseases.

References:

1. Chen, Guang, Liu, Tao, Yu, Bofan, Wang, Bingyi, Peng, Qiang. 2020. CircRNA-UBE2G1 regulates LPS-induced osteoarthritis through miR-373/HIF-1a axis. In Cell cycle (Georgetown, Tex.), 19, 1696-1705. doi:10.1080/15384101.2020.1772545. https://pubmed.ncbi.nlm.nih.gov/32476580/

2. Peng, Jia, Li, Wanbo, Wang, Bi, Han, Fang, Wang, Zhiyong. 2022. UBE2G1 Is a Critical Component of Immune Response to the Infection of Pseudomonas Plecoglossicida in Large Yellow Croaker (Larimichthys crocea). In International journal of molecular sciences, 23, . doi:10.3390/ijms23158298. https://pubmed.ncbi.nlm.nih.gov/35955424/

3. Lu, Gang, Weng, Stephanie, Matyskiela, Mary, Chamberlain, Philip, Rolfe, Mark. 2018. UBE2G1 governs the destruction of cereblon neomorphic substrates. In eLife, 7, . doi:10.7554/eLife.40958. https://pubmed.ncbi.nlm.nih.gov/30234487/

4. Masuda, Shusaku, Kurabayashi, Nobuhiro, Nunokawa, Rina, Yoshitane, Hikari, Fukada, Yoshitaka. 2024. TRAF7 determines circadian period through ubiquitination and degradation of DBP. In Communications biology, 7, 1280. doi:10.1038/s42003-024-07002-x. https://pubmed.ncbi.nlm.nih.gov/39379486/

5. Choi, Yun-Seok, Lee, Yun-Ju, Lee, Seo-Yeon, Cohen, Robert E, Ryu, Kyoung-Seok. 2014. Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities. In The Journal of biological chemistry, 290, 2251-63. doi:10.1074/jbc.M114.624809. https://pubmed.ncbi.nlm.nih.gov/25471371/

6. Sievers, Quinlan L, Gasser, Jessica A, Cowley, Glenn S, Fischer, Eric S, Ebert, Benjamin L. 2018. Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity. In Blood, 132, 1293-1303. doi:10.1182/blood-2018-01-821769. https://pubmed.ncbi.nlm.nih.gov/30042095/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest