C57BL/6NCya-Gp2em1/Cya
Common Name
Gp2-KO
Product ID
S-KO-12128
Backgroud
C57BL/6NCya
Strain ID
KOCMP-67133-Gp2-B6N-VA
When using this mouse strain in a publication, please cite “Gp2-KO Mouse (Catalog S-KO-12128) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Gp2-KO
Strain ID
KOCMP-67133-Gp2-B6N-VA
Gene Name
Product ID
S-KO-12128
Gene Alias
2310037I18Rik
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000033255
NCBI RefSeq
NM_025989
Target Region
Exon 3~7
Size of Effective Region
~4.6 kb
Overview of Gene Research
Gp2, or glycoprotein 2, has diverse functions. It was originally identified as a predominant membranous component of pancreatic acinar cells [3]. In mucosal immunology, it serves as a functional molecule specific for antigen-sampling cells in intestinal Peyer's patches, being involved in detecting pathological bacteria and identifying M cell lineage and their differentiation in lymphoid tissues [3,4].
In the context of pancreatic research, GP2-enriched pancreatic progenitors can give rise to all pancreatic cells in vivo, including functional beta-like cells, and eliminate the risk of teratomas, establishing GP2 sorting as an effective method for pancreatic progenitor purification and safe pancreatic differentiation [1]. Also, a novel PP differentiation platform based on compound screening can increase Glycoprotein-2 expression and trilineage potential, with GP2 expression levels at the PP stage ascribing varying pancreatic lineage potential [2].
In summary, Gp2 plays crucial roles in mucosal immunity and pancreatic cell differentiation. In mucosal tissues, it aids in pathogen detection and M-cell related processes. In pancreatic research, GP2-related studies offer insights into pancreatic cell development and potential treatment for diabetes-related conditions by ensuring safe pancreatic progenitor differentiation [1,2,3,4].
References:
1. Aghazadeh, Yasaman, Sarangi, Farida, Poon, Frankie, Nunes, Sara S, Nostro, M Cristina. 2022. GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation. In Stem cell reports, 17, 964-978. doi:10.1016/j.stemcr.2022.03.004. https://pubmed.ncbi.nlm.nih.gov/35364010/
2. Merz, Sarah, Breunig, Markus, Melzer, Michael Karl, Hohwieler, Meike, Kleger, Alexander. 2023. Single-cell profiling of GP2-enriched pancreatic progenitors to simultaneously create acinar, ductal, and endocrine organoids. In Theranostics, 13, 1949-1973. doi:10.7150/thno.78323. https://pubmed.ncbi.nlm.nih.gov/37064874/
3. Iwanaga, Toshihiko, Kimura, Shunsuke. . GP2-expressing cells: a new guardian with divergent functions in the intestine, eyes, and nose. In Biomedical research (Tokyo, Japan), 44, 233-243. doi:10.2220/biomedres.44.233. https://pubmed.ncbi.nlm.nih.gov/38008422/
4. Ohno, Hiroshi, Hase, Koji. . Glycoprotein 2 (GP2): grabbing the FimH bacteria into M cells for mucosal immunity. In Gut microbes, 1, 407-10. doi:10.4161/gmic.1.6.14078. https://pubmed.ncbi.nlm.nih.gov/21468225/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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