C57BL/6NCya-4930524B15Rikem1/Cya
Common Name:
4930524B15Rik-KO
Product ID:
S-KO-12352
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
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Contact for Pricing
Basic Information
Strain Name
4930524B15Rik-KO
Strain ID
KOCMP-67592-4930524B15Rik-B6N-VA
Gene Name
Product ID
S-KO-12352
Gene Alias
--
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
11
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-4930524B15Rikem1/Cya mice (Catalog S-KO-12352) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000102829
NCBI RefSeq
NM_026262
Target Region
Exon 1~4
Size of Effective Region
~11.1 kb
Detailed Document
Overview of Gene Research
4930524B15Rik, known as C5orf47 in human, is an evolutionarily conserved and testis-specific gene. Its exact associated pathways remain to be fully elucidated, but understanding its function is crucial for insights into spermatogenesis [1].
Using Nuclease technology technology to generate 4930524B15Rik knockout (KO) mice, it was found that 4930524B15Rik-/-mice were fertile. There were no observed abnormalities in testis morphology, epididymal sperm contents, sperm morphology, and the structure of seminiferous tubules along with the presence of all germ cell types was similar to wild-type. Cytological analysis of spermatocytes also showed no significant differences in prophase I progression of meiosis [1].
In conclusion, 4930524B15Rik is dispensable for male mouse fertility, as revealed by the KO mouse model. These findings help researchers avoid redundant research and focus on genes more crucial for spermatogenesis and reproduction [1].
References:
1. Khan, Ranjha, Ye, Jingwei, Yousaf, Ayesha, Shi, Qinghua, Jiang, Xiaohua. 2020. Evolutionarily conserved and testis-specific gene, 4930524B15Rik, is not essential for mouse spermatogenesis and fertility. In Molecular biology reports, 47, 5207-5213. doi:10.1007/s11033-020-05595-0. https://pubmed.ncbi.nlm.nih.gov/32592116/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen