C57BL/6JCya-Dcdc2cem1/Cya
Common Name:
Dcdc2c-KO
Product ID:
S-KO-12737
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Dcdc2c-KO
Strain ID
KOCMP-68511-Dcdc2c-B6J-VA
Gene Name
Product ID
S-KO-12737
Gene Alias
1110015M06Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
12
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Dcdc2cem1/Cya mice (Catalog S-KO-12737) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000249337
NCBI RefSeq
NM_001373956
Target Region
Exon 4~7
Size of Effective Region
~10.3 kb
Detailed Document
Overview of Gene Research
Dcdc2c, as of now, has been implicated in multiple biological contexts. In the context of sperm function, it may be associated with the assembly, organization, and dynamics of the flagellum microtubule, potentially playing a role in sperm motility and male fertility [1].
In human lung, it has been found that DNA methylation quantitative trait loci near Dcdc2c colocalize with chronic obstructive pulmonary disease (COPD) genome-wide association loci, suggesting a possible role in the pathogenesis of COPD [2].
In pigs, variants in/near Dcdc2c were associated with susceptibility to Salmonella, indicating its possible involvement in the host response to Salmonella infection [3].
In restless legs syndrome (RLS), in Caucasian populations, variants in Dcdc2c were associated with an increased risk of RLS, showing its potential link to this neurological disorder [4].
In the naked mole-rat, the loss of Dcdc2c gene was identified among several spermatozoa-related gene losses, which may be related to the unique degenerative sperm phenotype in this species [5].
In conclusion, Dcdc2c appears to have diverse functions, potentially in sperm-related processes, disease susceptibility such as in COPD and to Salmonella in pigs, and in the context of RLS. The gene loss studies in the naked mole-rat suggest its role in sperm characteristics. Further research, potentially including gene knockout or conditional knockout models, could provide more insights into its specific functions and contributions to these biological processes and disease conditions.
References:
1. Jumeau, Fanny, Chalmel, Frédéric, Fernandez-Gomez, Francisco-Jose, Sergeant, Nicolas, Mitchell, Valérie. . Defining the human sperm microtubulome: an integrated genomics approach. In Biology of reproduction, 96, 93-106. doi:10.1095/biolreprod.116.143479. https://pubmed.ncbi.nlm.nih.gov/28395323/
2. Morrow, Jarrett D, Glass, Kimberly, Cho, Michael H, Silverman, Edwin K, DeMeo, Dawn L. . Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci. In American journal of respiratory and critical care medicine, 197, 1275-1284. doi:10.1164/rccm.201707-1434OC. https://pubmed.ncbi.nlm.nih.gov/29313708/
3. Schut, Corinne H, Farzan, Abdolvahab, Fraser, Russell S, Friendship, Robert M, Lillie, Brandon N. 2020. Identification of single-nucleotide variants associated with susceptibility to Salmonella in pigs using a genome-wide association approach. In BMC veterinary research, 16, 138. doi:10.1186/s12917-020-02344-0. https://pubmed.ncbi.nlm.nih.gov/32414370/
4. Tan, Brendan Jen-Wei, Pang, Xin-Ler, Png, Sarah, Zhou, Zhi Dong, Tan, Eng-King. 2024. Genetic Association Studies in Restless Legs Syndrome: Risk Variants & Ethnic Differences. In The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, , 1-16. doi:10.1017/cjn.2024.8. https://pubmed.ncbi.nlm.nih.gov/38267254/
5. Sokolowski, Dustin J, Miclăuş, Mihai, Nater, Alexander, Balmus, Gabriel, Wilson, Michael D. 2024. An updated reference genome sequence and annotation reveals gene losses and gains underlying naked mole-rat biology. In bioRxiv : the preprint server for biology, , . doi:10.1101/2024.11.26.625329. https://pubmed.ncbi.nlm.nih.gov/39651266/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen