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C57BL/6JCya-Ak8em1/Cya
Common Name:
Ak8-KO
Product ID:
S-KO-12868
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ak8-KO
Strain ID
KOCMP-68870-Ak8-B6J-VA
Gene Name
Ak8
Product ID
S-KO-12868
Gene Alias
1190002A17Rik; AK 8
Background
C57BL/6JCya
NCBI ID
68870
Modification
Conventional knockout
Chromosome
2
Phenotype
MGI:1916120
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ak8em1/Cya mice (Catalog S-KO-12868) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000074156
NCBI RefSeq
NM_001033874
Target Region
Exon 7~11
Size of Effective Region
~25.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Ak8, an adenylate kinase, is crucial for efficient intracellular ATP transfer. It belongs to Subgroup III AKs, which are unique to the male reproductive system and conserved across chordates. Adenylate kinases are involved in maintaining adenine nucleotide homeostasis, an essential process for numerous cellular functions [1].

In knockout mouse models, Ak8 was found to be indispensable for male reproduction as it is central to promoting sperm motility. Ak8 interacts with the radial spoke (RS) of the axoneme, and together with Ak9, it cooperatively regulates ATP transfer in the axoneme, being concentrated at energy-consuming sites in the flagellum [1]. In addition, in Cfap45-deficient mice, microtubule sliding of dyskinetic sperm can be rescued with the addition of AMP or ADP along with ATP, suggesting a role of Ak8 in an adenine nucleotide homeostasis module associated with CFAP45 in ciliary and flagellar beating [2].

In conclusion, Ak8 plays a vital role in male reproduction, particularly in sperm motility, by regulating ATP transfer in the flagellar axoneme. The use of knockout mouse models has been instrumental in revealing these functions, which are relevant to understanding male infertility, a disease area where Ak8's role provides important insights into the underlying mechanisms [1,2].

References:

1. Wu, Huan, Zhang, Yanman, Li, Yuqian, Liu, Mingxi, He, Xiaojin. 2024. Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes. In Science China. Life sciences, 67, 1697-1714. doi:10.1007/s11427-023-2539-1. https://pubmed.ncbi.nlm.nih.gov/38761355/

2. Dougherty, Gerard W, Mizuno, Katsutoshi, Nöthe-Menchen, Tabea, Hamada, Hiroshi, Omran, Heymut. 2020. CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module. In Nature communications, 11, 5520. doi:10.1038/s41467-020-19113-0. https://pubmed.ncbi.nlm.nih.gov/33139725/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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