C57BL/6JCya-H2bl1em1/Cya
Common Name:
H2bl1-KO
Product ID:
S-KO-13052
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
H2bl1-KO
Strain ID
KOCMP-69382-H2bl1-B6J-VA
Gene Name
Product ID
S-KO-13052
Gene Alias
1700024P04Rik; Subh2bv
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
13
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-H2bl1em1/Cya mice (Catalog S-KO-13052) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000054425
NCBI RefSeq
NM_027064
Target Region
Exon 1
Size of Effective Region
~0.4 kb
Detailed Document
Overview of Gene Research
H2bl1, details about its aliases are not provided in the given reference. It is likely related to histone-associated functions as it may be involved in chromatin regulation processes [1]. Histones play crucial roles in packaging DNA into chromatin, which impacts gene expression and various cellular processes.
However, the provided reference is about α -synuclein's role as a histone chaperone and its interaction with histone complexes like H2a-H2b and (H3-H4)2, and there is no information regarding H2bl1 in this reference.
In conclusion, without relevant information from the reference, the specific biological functions of H2bl1 remain unclear. But given its potential histone-related nature, further research using gene knockout (KO) or conditional knockout (CKO) mouse models could potentially reveal its functions in chromatin-related biological processes and associated diseases.
References:
1. Jos, Sneha, Kambaru, Archanalakshmi, Prasad, Thazhe Kootteri, Padmanabhan, Balasundaram, Padavattan, Sivaraman. 2025. Structural and functional insights into the nuclear role of Parkinson's disease-associated α-synuclein as a histone chaperone. In Communications biology, 8, 712. doi:10.1038/s42003-025-08138-0. https://pubmed.ncbi.nlm.nih.gov/40341765/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen