C57BL/6JCya-Dydc1em1/Cya
Common Name
Dydc1-KO
Product ID
S-KO-13081
Backgroud
C57BL/6JCya
Strain ID
KOCMP-69496-Dydc1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Dydc1-KO Mouse (Catalog S-KO-13081) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Dydc1-KO
Strain ID
KOCMP-69496-Dydc1-B6J-VA
Gene Name
Product ID
S-KO-13081
Gene Alias
1700029M23Rik
Background
C57BL/6JCya
Gene Full Name
DPY30 domain containing 1
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 14 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000189865
NCBI Transcript ID
NM_027094
Target Region
Exon 2~7
Size of Effective Region
~13.3 kb
Overview of Gene Research
Dydc1 is a gene with important functions in specific biological processes. It is expressed exclusively in the brain and testis. In the context of spermatogenesis, Dydc1 plays a crucial role in acrosome biogenesis, which is essential for the proper differentiation of spermatids into spermatozoa [1].
Knockdown of endogenous Dydc1 in mouse spermiogenesis via RNA interference interfered with the formation of acrosomes, highlighting its significance in this process. This indicates that Dydc1 is necessary for the normal development of sperm's acrosome, a structure that enables sperm to penetrate the egg [1].
In summary, Dydc1 is vital for acrosome biogenesis during spermiogenesis. Studies using mouse models with Dydc1 knockdown have provided key insights into the gene's function in this aspect of male reproductive biology, contributing to our understanding of spermatogenesis and potentially male infertility related to acrosome formation defects.
References:
1. Li, Shuchun, Qiao, Yuan, Di, Qian, Miao, Shiying, Wang, Lingfang. 2009. Interaction of SH3P13 and DYDC1 protein: a germ cell component that regulates acrosome biogenesis during spermiogenesis. In European journal of cell biology, 88, 509-20. doi:10.1016/j.ejcb.2009.05.001. https://pubmed.ncbi.nlm.nih.gov/19545932/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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