C57BL/6NCya-Mamdc2em1/Cya
Common Name
Mamdc2-KO
Product ID
S-KO-13649
Backgroud
C57BL/6NCya
Strain ID
KOCMP-71738-Mamdc2-B6N-VA
Status
When using this mouse strain in a publication, please cite “Mamdc2-KO Mouse (Catalog S-KO-13649) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Mamdc2-KO
Strain ID
KOCMP-71738-Mamdc2-B6N-VA
Gene Name
Product ID
S-KO-13649
Gene Alias
mamcan, 1200015L10Rik
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000036069
NCBI RefSeq
NM_174857
Target Region
Exon 3
Size of Effective Region
~0.3 kb
Overview of Gene Research
MAMDC2, a gene encoding a putative extracellular matrix protein, has diverse functions. It is involved in the innate antiviral response in microglia and may play a role in the link between HSV-1 and Alzheimer's disease. It also has potential implications in cell proliferation, skeletal muscle physiology, and may be associated with multiple disease-related pathways [1,2].
In genetic studies, Mamdc2-deficient (Mamdc2-/-) mice are more susceptible to HSV-1 infection, showing an impaired type I interferon-based innate antiviral response. This indicates that MAMDC2 positively regulates the innate antiviral response during neurotropic virus infection. Mechanistically, MAMDC2 interacts with STING via its first MAM domain, enhancing STING polymerization and activating downstream TBK1-IRF3 signaling to promote the expression of I-IFNs [1].
In conclusion, MAMDC2 has essential functions in the innate antiviral response in microglia, as revealed through gene-knockout mouse models. Its role in this process provides insights into the potential mechanism connecting HSV-1 and Alzheimer's disease, highlighting the importance of MAMDC2 in understanding the pathogenesis of such neurological diseases.
References:
1. Wang, Yiliang, Luo, Weisheng, Wang, Xiaohui, Huang, Lianzhou, Wang, Yifei. 2021. MAMDC2, a gene highly expressed in microglia in experimental models of Alzheimers Disease, positively regulates the innate antiviral response during neurotropic virus infection. In The Journal of infection, 84, 187-204. doi:10.1016/j.jinf.2021.12.004. https://pubmed.ncbi.nlm.nih.gov/34902449/
2. Mavillard, Fabiola, Servian-Morilla, Emilia, Dofash, Lein, Ravenscroft, Gianina, Cabrera-Serrano, Macarena. . Ablation of the carboxy-terminal end of MAMDC2 causes a distinct muscular dystrophy. In Brain : a journal of neurology, 146, 5235-5248. doi:10.1093/brain/awad256. https://pubmed.ncbi.nlm.nih.gov/37503746/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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