C57BL/6JCya-Cdaem1/Cya
Common Name
Cda-KO
Product ID
S-KO-13886
Backgroud
C57BL/6JCya
Strain ID
KOCMP-72269-Cda-B6J-VA
Status
When using this mouse strain in a publication, please cite “Cda-KO Mouse (Catalog S-KO-13886) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Cda-KO
Strain ID
KOCMP-72269-Cda-B6J-VA
Gene Name
Product ID
S-KO-13886
Gene Alias
2210401N16Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000030535
NCBI RefSeq
NM_028176
Target Region
Exon 2~3
Size of Effective Region
~7.8 kb
Overview of Gene Research
Cda, short for cytidine deaminase, is an enzyme-coding gene. The cytidine deaminase it encodes is responsible for detoxifying cytarabine (Ara-C) in the liver. Cda is highly polymorphic, and its activity can impact the toxicity and efficacy of Ara-C treatment in acute myeloid leukemia (AML) [1].
In a study on 58 adult AML patients treated with the standard 7 + 3 (Ara-C + anthracyclines) protocol, those experiencing severe/lethal toxicities had significantly lower Cda activity (1.5 ± 0.7 U/mg vs 3.95 ± 3.1 U/mg, Student t test P <.001). A Cda activity threshold of 2 U/mg was associated with a poor metabolizer syndrome and an increased risk of severe toxicities. Also, patients with low Cda activity showed a trend towards higher response rates and longer progression-free and overall survival [1].
In conclusion, Cda is crucial in determining the toxicities and efficacy of cytarabine-based chemotherapy in AML. Understanding the role of Cda through such in-vivo-like human patient-based studies helps in predicting treatment-related risks in AML patients, potentially guiding more personalized treatment strategies.
References:
1. Fanciullino, Raphaelle, Farnault, Laure, Donnette, Mélanie, Lacarelle, Bruno, Costello, Regis. . CDA as a predictive marker for life-threatening toxicities in patients with AML treated with cytarabine. In Blood advances, 2, 462-469. doi:10.1182/bloodadvances.2017014126. https://pubmed.ncbi.nlm.nih.gov/29490977/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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