C57BL/6JCya-Spats2em1/Cya
Common Name
Spats2-KO
Product ID
S-KO-13982
Backgroud
C57BL/6JCya
Strain ID
KOCMP-72572-Spats2-B6J-VA
When using this mouse strain in a publication, please cite “Spats2-KO Mouse (Catalog S-KO-13982) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Spats2-KO
Strain ID
KOCMP-72572-Spats2-B6J-VA
Gene Name
Product ID
S-KO-13982
Gene Alias
2700012F11Rik, 59kDa, Scr59, p59, p59scr
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 15
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000063517
NCBI RefSeq
NM_139140
Target Region
Exon 4~7
Size of Effective Region
~7.4 kb
Overview of Gene Research
Spats2, short for spermatogenesis associated serine rich 2, is a member of the RNA-binding protein family. It plays crucial roles in multiple biological processes, with its abnormal expression being linked to carcinogenesis. It is associated with pathways such as cell cycle, apoptosis, and cancer cell metastasis, which are vital in understanding normal cellular functions and disease development [1,2].
In hepatocellular carcinoma (HCC), elevated Spats2 expression is unfavorably associated with clinical pathological stage and prognosis. Knockdown of Spats2 in HCC cell lines affects cell cycle, apoptosis, and invasion, indicating its oncogenic role [1]. In esophageal squamous cell carcinoma (ESCC) cell lines, silencing Spats2 suppresses cell proliferation, migration, and invasion [3]. These loss-of-function experiments suggest Spats2 promotes cancer progression in these malignancies.
In conclusion, Spats2 is an important gene with oncogenic potential in cancers like HCC and ESCC. The study of Spats2 through loss-of-function models has provided insights into its role in cancer-related biological processes, highlighting its potential as a diagnostic and prognostic biomarker, as well as a therapeutic target in these disease areas [1,3].
References:
1. Lin, Jing, Yan, Jia, Deng, Xiu Ling, Wang, Chang Shan, Wang, Hai Sheng. 2023. SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma. In BMC gastroenterology, 23, 8. doi:10.1186/s12876-022-02633-y. https://pubmed.ncbi.nlm.nih.gov/36631750/
2. Dong, Gang, Zhang, Shanshan, Shen, Shen, Rao, Benchen, Ren, Zhigang. 2020. SPATS2, negatively regulated by miR-145-5p, promotes hepatocellular carcinoma progression through regulating cell cycle. In Cell death & disease, 11, 837. doi:10.1038/s41419-020-03039-y. https://pubmed.ncbi.nlm.nih.gov/33037180/
3. Liu, Yan-Peng, Cao, Qiuhong, Li, Ling, Zhang, Min. 2021. High expression of spermatogenesis associated serine rich 2 promotes tumorigenicity in esophageal squamous cell carcinoma cells and is associated with poor patient prognosis. In Experimental and therapeutic medicine, 22, 698. doi:10.3892/etm.2021.10130. https://pubmed.ncbi.nlm.nih.gov/33986862/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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