Prrc1, a gene with no common aliases indicated in the provided references, is involved in multiple biological functions. It contains a proline-rich domain and regulates anterograde trafficking. It is recruited to endoplasmic reticulum (ER) exit sites, interacts with the inner COPII coat, and influences membrane association of COPII, thus playing a role in the protein transport in the secretory pathway [2].

In secondary acute lymphoblastic leukemia (sALL), an in-frame fusion between 5'MLL and 3'PRRC1 was found in a patient, suggesting its potential involvement in this disease [1]. In head and neck cancer (HNC), PRRC1 was identified as an independent prognostic factor through systematic analysis of survival-associated alternative splicing signatures [4]. Also, in a study on the impact of life adversity and gene expression on psychiatric symptoms in children and adolescents, PRRC1 was negatively associated with deprivation [5]. A region on chromosome 5 spanning the PRRC1 gene was significant at a genome-wide 10% empirical threshold in relation to fluid intelligence, and gene methylation analysis provided support for the association between PRRC1 and fluid intelligence [3].

In conclusion, Prrc1 is important in protein trafficking and has potential associations with various diseases and cognitive function. Findings from different research areas such as leukemia, cancer, mental health, and intelligence research, though not from KO/CKO mouse models in the given references, suggest its diverse roles in biological processes and disease conditions, which can provide a basis for further in-depth functional studies.

References:

1. Douet-Guilbert, Nathalie, Eveillard, Jean-Richard, Meyer, Claus, Marschalek, Rolf, De Braekeleer, Marc. 2014. MLL partner genes in secondary acute lymphoblastic leukemia: report of a new partner PRRC1 and review of the literature. In Leukemia research, 38, 1316-9. doi:10.1016/j.leukres.2014.08.011. https://pubmed.ncbi.nlm.nih.gov/25205603/

2. Huang, Yan, Yin, Haidi, Li, Baiying, Yao, Zhong-Ping, Guo, Yusong. . An in vitro vesicle formation assay reveals cargo clients and factors that mediate vesicular trafficking. In Proceedings of the National Academy of Sciences of the United States of America, 118, . doi:10.1073/pnas.2101287118. https://pubmed.ncbi.nlm.nih.gov/34433667/

3. Rowe, Suzanne J, Rowlatt, Amy, Davies, Gail, Deary, Ian J, Tenesa, Albert. 2013. Complex variation in measures of general intelligence and cognitive change. In PloS one, 8, e81189. doi:10.1371/journal.pone.0081189. https://pubmed.ncbi.nlm.nih.gov/24349040/

4. Liang, Ying, Song, Jukun, He, Dengqi, Yin, Xinhai, Liu, Jianguo. 2019. Systematic analysis of survival-associated alternative splicing signatures uncovers prognostic predictors for head and neck cancer. In Journal of cellular physiology, 234, 15836-15846. doi:10.1002/jcp.28241. https://pubmed.ncbi.nlm.nih.gov/30740675/

5. Ota, Vanessa Kiyomi, Oliveira, Adrielle Martins, Bugiga, Amanda Victória Gomes, Carvalho, Carolina Muniz, Belangero, Sintia Iole. 2025. Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study. In Frontiers in psychiatry, 16, 1505421. doi:10.3389/fpsyt.2025.1505421. https://pubmed.ncbi.nlm.nih.gov/40018685/