C57BL/6JCya-3110082I17Rikem1/Cya
Common Name:
3110082I17Rik-KO
Product ID:
S-KO-14102
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
3110082I17Rik-KO
Strain ID
KOCMP-73212-3110082I17Rik-B6J-VA
Gene Name
Product ID
S-KO-14102
Gene Alias
-
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-3110082I17Rikem1/Cya mice (Catalog S-KO-14102) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000066052
NCBI RefSeq
NM_028469
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
3110082I17Rik, an ortholog of human C7orf50, encodes a hormone named Cholesin. Cholesin is involved in the regulation of cholesterol metabolism, playing a crucial role in maintaining cholesterol homeostasis through its associated pathway of inhibiting PKA signaling to suppress SREBP2-controlled cholesterol synthesis. Genetic models, like mouse models, are valuable for studying its function [1].
In mice, 3110082I17Rik-encoded Cholesin is secreted from the intestine in response to cholesterol absorption. It binds to GPR146, an orphan G-protein-coupled receptor. Through this interaction, it inhibits PKA signaling, which in turn suppresses SREBP2-controlled cholesterol synthesis in the liver, reducing circulating cholesterol levels. This reveals that the Cholesin-GPR146 axis mediates the inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis [1].
In conclusion, 3110082I17Rik, via encoding Cholesin, is essential for regulating cholesterol metabolism. The study of 3110082I17Rik in mouse models contributes to understanding its role in maintaining cholesterol homeostasis, holding promise for combating hypercholesterolemia and atherosclerosis [1].
References:
1. Hu, Xiaoli, Chen, Fengyi, Jia, Liangjie, Zhang, Huijie, Wang, Yiguo. 2024. A gut-derived hormone regulates cholesterol metabolism. In Cell, 187, 1685-1700.e18. doi:10.1016/j.cell.2024.02.024. https://pubmed.ncbi.nlm.nih.gov/38503280/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen