C57BL/6NCya-Trmt11em1/Cya
Common Name:
Trmt11-KO
Product ID:
S-KO-14185
Background:
C57BL/6NCya
Product Type
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Genotype
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Basic Information
Strain Name
Trmt11-KO
Strain ID
KOCMP-73681-Trmt11-B6N-VA
Gene Name
Product ID
S-KO-14185
Gene Alias
2410075D05Rik; 3110045I18Rik
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Trmt11em1/Cya mice (Catalog S-KO-14185) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000019927
NCBI RefSeq
NM_028604
Target Region
Exon 3~7
Size of Effective Region
~6.8 kb
Detailed Document
Overview of Gene Research
Trmt11 is a gene encoding a protein that is part of the methyltransferase family. It is allosterically regulated by human TRMT112 and is involved in N2-methylguanosine (m2G) modification of tRNAs. m2G modifications on non-coding RNAs like tRNAs are crucial for cell proliferation, protein translation, and thus play a significant role in gene expression regulation [1].
One key finding is that TRMT11 is a direct partner of TRMT112, and together with other associated methyltransferases, it forms a network. TRMT11 has been identified as an active m2G methyltransferase, specifically methylating position 10 of tRNAs, which is important for optimal protein synthesis and cell proliferation [1]. Also, gene fusions involving Trmt11, such as TRMT11-GRIK2, have been found in multiple cancer types including breast, colon, non-small cell lung, esophageal adenocarcinoma, glioblastoma multiforme, ovarian, and liver cancers, as well as in lymph node metastatic cancer samples from the breast, colon, and ovary, indicating potential biological and clinical implications in cancer patient management [2].
In conclusion, Trmt11 is essential for tRNA m2G modification, which is vital for protein synthesis and cell proliferation. The discovery of its gene fusions in various cancers through in vivo-like studies on cancer samples highlights its potential significance in cancer-related biological processes. Understanding Trmt11's functions may offer new insights into the mechanisms of cell growth regulation and cancer development [1,2].
References:
1. Wang, Can, Ulryck, Nathalie, Herzel, Lydia, Bohnsack, Katherine E, Graille, Marc. . N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing. In Nucleic acids research, 51, 7496-7519. doi:10.1093/nar/gkad487. https://pubmed.ncbi.nlm.nih.gov/37283053/
2. Yu, Yan-Ping, Liu, Peng, Nelson, Joel, Tseng, George, Luo, Jian-Hua. 2019. Identification of recurrent fusion genes across multiple cancer types. In Scientific reports, 9, 1074. doi:10.1038/s41598-019-38550-6. https://pubmed.ncbi.nlm.nih.gov/30705370/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen