C57BL/6JCya-Psdem1/Cya
Common Name
Psd-KO
Product ID
S-KO-14199
Backgroud
C57BL/6JCya
Strain ID
KOCMP-73728-Psd-B6J-VA
Status
When using this mouse strain in a publication, please cite “Psd-KO Mouse (Catalog S-KO-14199) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Psd-KO
Strain ID
KOCMP-73728-Psd-B6J-VA
Gene Name
Product ID
S-KO-14199
Gene Alias
Efa6, Psdl, Efa6a, mKIAA2011, A930015K15, 1110007H17Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000041391
NCBI RefSeq
NM_028627
Target Region
Exon 3~15
Size of Effective Region
~10.8 kb
Overview of Gene Research
Psd may refer to two main concepts. One is related to Post-stroke depression, where "PSD" is an abbreviation. Post-stroke depression is a common and serious sequela of stroke, affecting approximately 18-41% of stroke survivors within 2 years [1,3]. It is associated with higher mortality, poorer recovery, more pronounced cognitive deficits, and lower quality of life. The pathophysiology is multifactorial, involving decreased levels of monoamines, abnormal neurotrophic response, increased inflammation with dysregulation of hypothalamic-pituitary-adrenal axis, and glutamate-mediated excitotoxicity [1].
The other refers to the postsynaptic density protein-95 (PSD-95), encoded by the DLG4 gene. PSD-95 is a scaffolding protein in the postsynaptic density of excitatory neurons, crucial for synaptic strength and plasticity. It organizes key PSD components essential for synaptic signaling, development, and survival [2]. Variants in DLG4 encoding PSD-95 can cause a neurodevelopmental disorder with features like intellectual disability, developmental delay, and epilepsy [2].
In conclusion, Post-stroke depression (PSD) is a significant complication of stroke with complex pathophysiology, while PSD-95 is a key protein in synaptic function and its genetic variants are linked to neurodevelopmental disorders. The study of these aspects of Psd helps in understanding the mechanisms of stroke-related depression and neurodevelopmental problems, potentially leading to better treatment strategies.
References:
1. Medeiros, Gustavo C, Roy, Durga, Kontos, Nicholas, Beach, Scott R. 2020. Post-stroke depression: A 2020 updated review. In General hospital psychiatry, 66, 70-80. doi:10.1016/j.genhosppsych.2020.06.011. https://pubmed.ncbi.nlm.nih.gov/32717644/
2. Levy, Amanda M, Gomez-Puertas, Paulino, Tümer, Zeynep. 2022. Neurodevelopmental Disorders Associated with PSD-95 and Its Interaction Partners. In International journal of molecular sciences, 23, . doi:10.3390/ijms23084390. https://pubmed.ncbi.nlm.nih.gov/35457207/
3. Guo, Jianglong, Wang, Jinjing, Sun, Wen, Liu, Xinfeng. 2021. The advances of post-stroke depression: 2021 update. In Journal of neurology, 269, 1236-1249. doi:10.1007/s00415-021-10597-4. https://pubmed.ncbi.nlm.nih.gov/34052887/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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