C57BL/6JCya-Spatc1em1/Cya
Common Name
Spatc1-KO
Product ID
S-KO-14370
Backgroud
C57BL/6JCya
Strain ID
KOCMP-74281-Spatc1-B6J-VA
When using this mouse strain in a publication, please cite “Spatc1-KO Mouse (Catalog S-KO-14370) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Spatc1-KO
Strain ID
KOCMP-74281-Spatc1-B6J-VA
Gene Name
Product ID
S-KO-14370
Gene Alias
1700084J23Rik, speriolin
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 15
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000074173
NCBI RefSeq
NM_028852
Target Region
Exon 2~4
Size of Effective Region
~1.5 kb
Overview of Gene Research
Spatc1, or Spermatogenesis and Centriole Associated 1, is a gene with a significant role in spermatogenesis. It is associated with pathways related to sperm function and male reproduction. Genetic models, such as mouse models, can be valuable for studying its functions [1,2].
In mice, chronic administration of ghrelin, which impairs spermatogenesis, leads to a relative decrease in Spatc1 expression, suggesting its involvement in the process regulated by ghrelin [3]. Also, male mice with a truncation mutation in Basonuclin 1 (BNC1) exhibit fertility loss and testicular premature aging, and Spatc1 was identified as one of the spermatogenesis-specific gene promoters targeted by BNC1, indicating a cooperative role in regulating spermatogenesis [4].
In conclusion, Spatc1 is crucial for spermatogenesis and male reproduction. Mouse models, especially those with mutations affecting Spatc1 expression, have provided insights into its role in processes related to male fertility, helping to understand the mechanisms underlying infertility and testicular aging [3,4].
References:
1. Liu, Xu, Liu, Xuyuan, Wang, Xinqi, He, Miao, Fan, Zhenxin. 2023. Multi-omics analysis reveals changes in tryptophan and cholesterol metabolism before and after sexual maturation in captive macaques. In BMC genomics, 24, 308. doi:10.1186/s12864-023-09404-3. https://pubmed.ncbi.nlm.nih.gov/37286946/
2. An, Yeeun, Lee, Chaeyoung. 2022. Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance. In Computational biology and chemistry, 99, 107713. doi:10.1016/j.compbiolchem.2022.107713. https://pubmed.ncbi.nlm.nih.gov/35709667/
3. Belén Poretti, María, Bianconi, Santiago, Luque, Eugenia, Schiöth, Helgi B, Carlini, Valeria Paola. 2022. Role of the hypothalamus in ghrelin effects on reproduction: sperm function and sexual behavior in male mice. In Reproduction (Cambridge, England), 165, 123-134. doi:10.1530/REP-22-0098. https://pubmed.ncbi.nlm.nih.gov/36322468/
4. Li, Jing-Yi, Liu, Yi-Feng, Xu, Hai-Yan, Zhang, Dan, Huang, He-Feng. . Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis. In Journal of molecular cell biology, 12, 71-83. doi:10.1093/jmcb/mjz035. https://pubmed.ncbi.nlm.nih.gov/31065688/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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