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C57BL/6JCya-Lrrc17em1/Cya
Common Name:
Lrrc17-KO
Product ID:
S-KO-14452
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Lrrc17-KO
Strain ID
KOCMP-74511-Lrrc17-B6J-VA
Gene Name
Lrrc17
Product ID
S-KO-14452
Gene Alias
37kDa; 4833425M04Rik; 6130400C22Rik; P37nb
Background
C57BL/6JCya
NCBI ID
74511
Modification
Conventional knockout
Chromosome
5
Phenotype
MGI:1921761
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lrrc17em1/Cya mice (Catalog S-KO-14452) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000035651
NCBI RefSeq
NM_028977.1
Target Region
Exon 2
Size of Effective Region
~0.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Lrrc17, leucine-rich repeat containing 17, is involved in multiple biological processes. It is related to pathways like mTOR/PI3K, Wnt, and p53-dependent apoptosis, playing an important role in cell senescence, differentiation, and bone metabolism [1,2,3]. Genetic models are valuable for studying its function.

In bone marrow-derived mesenchymal stem cells (BMSCs), Lrrc17 knockdown activates mitophagy via the mTOR/PI3K pathway, rejuvenates senescent BMSCs, and enhances their therapeutic efficacy in osteoporosis by inhibiting BMSC senescence [1]. In ovarian cancer, knockdown of lrrc17 in zebrafish embryos reduces the survival rate and delays development, indicating its importance in cell viability through the p53-dependent apoptosis pathway [2]. In human bone marrow mesenchymal stem cells from patients with idiopathic necrosis of femoral head, overexpression of LRRC17 promotes osteogenesis and inhibits adipogenesis via the Wnt signaling pathway, while knockout has the opposite effects [3]. In cardiac fibroblasts after myocardial infarction, down-regulation of LRRc17 is associated with increased ferroptosis-related markers and enhanced cell migration and viability, and oe-LRRc17 treatment can reverse these effects [4].

In conclusion, Lrrc17 is crucial in cell-related biological processes and diseases. Its role in BMSC-related bone diseases, ovarian cancer, and myocardial fibrosis has been revealed through gene-knockout or knockdown models. These findings contribute to understanding the mechanisms of these diseases and may provide potential therapeutic targets.

References:

1. Liu, Fei, Yuan, Yujia, Bai, Lin, Cheng, Jingqiu, Zhang, Jie. 2021. LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss. In Redox biology, 43, 101963. doi:10.1016/j.redox.2021.101963. https://pubmed.ncbi.nlm.nih.gov/33865167/

2. Oh, Chang-Kyu, Park, Jeong Jun, Ha, Mihyang, Ko, Dai Sik, Kim, Yun Hak. . LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function. In Anticancer research, 40, 5601-5609. doi:10.21873/anticanres.14573. https://pubmed.ncbi.nlm.nih.gov/32988884/

3. Song, Da, Wu, Zhen-Song, Xu, Qi, Zhang, Chao, Wang, Da-Wei. 2021. LRRC17 regulates the bone metabolism of human bone marrow mesenchymal stem cells from patients with idiopathic necrosis of femoral head through Wnt signaling pathways: A preliminary report. In Experimental and therapeutic medicine, 22, 666. doi:10.3892/etm.2021.10098. https://pubmed.ncbi.nlm.nih.gov/33986831/

4. Hu, Yao, Peng, Xiaoping. 2024. Single-cell sequencing reveals LRRc17-mediated modulation of cardiac fibroblast ferroptosis in regulating myocardial fibrosis after myocardial infarction. In Cellular signalling, 121, 111293. doi:10.1016/j.cellsig.2024.111293. https://pubmed.ncbi.nlm.nih.gov/38996956/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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