C57BL/6JCya-Rab3il1em1/Cya
Common Name:
Rab3il1-KO
Product ID:
S-KO-14514
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Rab3il1-KO
Strain ID
KOCMP-74760-Rab3il1-B6J-VA
Gene Name
Product ID
S-KO-14514
Gene Alias
1200014K04Rik; Rab3ail1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
19
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rab3il1em1/Cya mice (Catalog S-KO-14514) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000238672
NCBI RefSeq
NM_001378859.1
Target Region
Exon 2~9
Size of Effective Region
~5.9 kb
Detailed Document
Overview of Gene Research
Rab3il1, also known as GRAB (guanine nucleotide exchange factor for Rab3A; RAB3A interacting protein (rabin3)-like 1), acts as a guanine nucleotide exchange factor (GEF) for Rab3a, Rab8a, and Rab8b, and is a binding partner for Rab11a and Rab11b [3]. It is involved in multiple intracellular trafficking processes, which are crucial for various cellular functions. These pathways include the regulation of transferrin receptor recycling and iron uptake during erythropoiesis [5], and the control of lysosome exocytosis [6].
In congenital diaphragmatic hernia (CDH) patients, Rab3il1 was among the differentially regulated genes, suggesting its potential involvement in angiogenesis related to CDH etiology [1]. In unstable atherosclerotic plaque research, Rab3il1 was identified as a hub gene, potentially providing new targets for diagnosis and therapy [2]. In hepatocellular carcinoma, Rab3il1 was one of the 9 mRNAs identified as a prognostic indicator, and its inclusion in a genomic-clinicopathologic nomogram improved the prediction of patient mortality [4].
In conclusion, Rab3il1 is a significant gene involved in intracellular trafficking-related functions. Its role in diseases such as CDH, unstable atherosclerotic plaque, and hepatocellular carcinoma, as revealed through various studies, highlights its importance in understanding disease mechanisms. These findings from disease-related research contribute to potentially developing new diagnostic and therapeutic strategies for these conditions.
References:
1. Gürünlüoğlu, Kubilay, Dündar, Muhammed, Unver, Turgay, Demircan, Mehmet, Koc, Ahmet. 2022. Global gene expression profiling in congenital diaphragmatic hernia (CDH) patients. In Functional & integrative genomics, 22, 359-369. doi:10.1007/s10142-022-00837-9. https://pubmed.ncbi.nlm.nih.gov/35260975/
2. Zhang, Rui, Ji, Zhenjun, Yao, Yuyu, Ma, Genshan, Li, Yongjun. 2020. Identification of hub genes in unstable atherosclerotic plaque by conjoint analysis of bioinformatics. In Life sciences, 262, 118517. doi:10.1016/j.lfs.2020.118517. https://pubmed.ncbi.nlm.nih.gov/33011223/
3. Horgan, Conor P, Hanscom, Sara R, McCaffrey, Mary W. 2013. GRAB is a binding partner for the Rab11a and Rab11b GTPases. In Biochemical and biophysical research communications, 441, 214-9. doi:10.1016/j.bbrc.2013.10.043. https://pubmed.ncbi.nlm.nih.gov/24140058/
4. Ni, Fu-Biao, Lin, Zhuo, Fan, Xu-Hui, Wang, Xiao-Dong, Chen, Rui-Cong. 2020. A novel genomic-clinicopathologic nomogram to improve prognosis prediction of hepatocellular carcinoma. In Clinica chimica acta; international journal of clinical chemistry, 504, 88-97. doi:10.1016/j.cca.2020.02.001. https://pubmed.ncbi.nlm.nih.gov/32032609/
5. Chen, Mengying, Zhang, Yuhan, Jiang, Kailun, Shi, Jiahai, Chen, Caiyong. . Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts. In Blood, 140, 1145-1155. doi:10.1182/blood.2021015189. https://pubmed.ncbi.nlm.nih.gov/35820059/
6. Escrevente, Cristina, Bento-Lopes, Liliana, Ramalho, José S, Barral, Duarte C. 2021. Rab11 is required for lysosome exocytosis through the interaction with Rab3a, Sec15 and GRAB. In Journal of cell science, 134, . doi:10.1242/jcs.246694. https://pubmed.ncbi.nlm.nih.gov/34100549/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen