C57BL/6JCya-Ct55em1/Cya
Common Name
Ct55-KO
Product ID
S-KO-14552
Backgroud
C57BL/6JCya
Strain ID
KOCMP-75013-Ct55-B6J-VA
When using this mouse strain in a publication, please cite “Ct55-KO Mouse (Catalog S-KO-14552) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ct55-KO
Strain ID
KOCMP-75013-Ct55-B6J-VA
Gene Name
Product ID
S-KO-14552
Gene Alias
4930502E18Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000069209
NCBI RefSeq
NM_029142
Target Region
Exon 2~4
Size of Effective Region
~9.0 kb
Overview of Gene Research
Ct55, a Cancer/Testis Antigen (CTA) gene, has its physiological expression restricted to the testis but is activated in many human cancers. It functions as an autophagic manipulator, interacting with LAMP2 and GABARAP (key autophagy regulators) to regulate spermatogenesis. Also, it is involved in pathways related to cancer cell proliferation, mitochondrial DNA maintenance, and NF-κB signaling [1,2,3]. Genetic models, like gene knockout mouse models, are valuable for studying Ct55's functions.
In gene knockout mouse models, depletion of Ct55 led to male infertility in mice, mimicking human sperm individualization defects, excessive cytoplasm residue, and acrosome development issues [1]. In cancer-related studies, CT55 silencing decreased cancer cell proliferation, reduced mtDNA copy number, and attenuated colitis-associated colorectal cancer by inhibiting NF-κB signaling [2,3].
In conclusion, Ct55 plays essential roles in spermatogenesis and cancer-related biological processes. The gene knockout mouse models have revealed its significance in male infertility and in promoting certain cancers, thus providing insights into potential therapeutic targets for infertility and cancers such as colitis-associated colorectal cancer.
References:
1. Zhang, Guohui, Jiang, Chuan, Yang, Yushang, Yang, Yihong, Shen, Ying. 2022. Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice. In Cell death and differentiation, 30, 500-514. doi:10.1038/s41418-022-01098-6. https://pubmed.ncbi.nlm.nih.gov/36481789/
2. Aurrière, Jade, Goudenege, David, Baechler, Simone A, Lenaers, Guy, Khiati, Salim. 2022. Cancer/Testis Antigen 55 is required for cancer cell proliferation and mitochondrial DNA maintenance. In Mitochondrion, 64, 19-26. doi:10.1016/j.mito.2022.02.005. https://pubmed.ncbi.nlm.nih.gov/35189384/
3. Zhao, Huan, Pan, Wen-Ming, Zhang, Hui-Hui, Du, Run-Lei, Zhang, Xiao-Dong. 2019. Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-κB signaling. In Cell death & disease, 10, 304. doi:10.1038/s41419-019-1537-x. https://pubmed.ncbi.nlm.nih.gov/30944312/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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