C57BL/6JCya-Cep43em1/Cya
Common Name:
Cep43-KO
Product ID:
S-KO-14599
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Cep43-KO
Strain ID
KOCMP-75296-Cep43-B6J-VA
Gene Name
Product ID
S-KO-14599
Gene Alias
4930553O10Rik; FOP; Fgfr1op
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
17
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cep43em1/Cya mice (Catalog S-KO-14599) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000097419
NCBI RefSeq
NM_001197046
Target Region
Exon 3
Size of Effective Region
~0.5 kb
Detailed Document
Overview of Gene Research
Cep43, also known as centrosomal protein 43, plays a crucial role in cilia-related processes. Cilia are important organelles for signaling and locomotion in eukaryotic cells, and Cep43 is involved in the assembly of IFT complexes into IFT trains for ciliary entry. It functions through specific domain-mediated interactions within the ciliary base complex [1].
Structural modeling suggests that the N-terminal domain of Cep43 forms a homo-dimer. This dimer anchors at the subdistal appendages of cilia by directly interacting with CEP350. A long linker separates this N-terminal domain from the C-terminal domain, which captures CEP19 above the subdistal appendages and near the distal appendages. These interactions are vital for the proper architecture of RabL2-associated complexes at the ciliary base, and thus for ciliary entry [1].
In conclusion, Cep43 is essential for the structural organization of ciliary complexes, specifically in the process of IFT train assembly and ciliary entry. Understanding the function of Cep43 through structural modeling provides insights into ciliary-related biological processes. Although no KO/CKO mouse models were mentioned in the provided references, the findings highlight its importance in ciliary function and potentially related diseases where ciliary function is disrupted [1].
References:
1. Boegholm, Niels, Petriman, Narcis A, Tanvir, Niaj M, Lorentzen, Esben. 2024. Architecture of RabL2-associated complexes at the ciliary base: A structural modeling perspective: Deciphering the structural organization of ciliary RabL2 complexes. In BioEssays : news and reviews in molecular, cellular and developmental biology, 46, e2300222. doi:10.1002/bies.202300222. https://pubmed.ncbi.nlm.nih.gov/38991980/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen